Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 6/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 6/20 | 0.51 |
| ▸ | CDK2 | P24941 | 5/20 | 0.51 |
| ▸ | GSK3B | P49841 | 5/20 | 0.51 |
| ▸ | IRAK4 | Q9NWZ3 | 5/20 | 0.51 |
| ▸ | CDC7 | O00311 | 3/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.51 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.51 |
| ▸ | PRKACA | P17612 | 2/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 10/20 | 0.47 |
| ▸ | BACE1 | P56817 | 4/20 | 0.44 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 5/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 3/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.42 |
| ▸ | PIM1 | P11309 | 3/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.42 |
| ▸ | GSK3A | P49840 | 3/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.42 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4859172 | 0.87 | CHEK1 (0.50) | MAP4K4CLK4CDK2GSK3BIRAK4 | |
| SCHEMBL4858583 | 0.84 | CHEK1 (0.49) | MAP4K4CLK4CDK2GSK3BIRAK4 | |
| SCHEMBL4850428 | 0.83 | CDC7 (0.71) | MAP4K4CLK4CDK2GSK3BIRAK4 | |
| SCHEMBL4850248 | 0.78 | CHEK1 (0.64) | MAP4K4CLK4CDK2GSK3BIRAK4 | |
| SCHEMBL4849727 | 0.74 | CHEK1 (0.73) | MAP4K4CLK4CDK2GSK3BIRAK4 | |
| SCHEMBL4851403 | 0.74 | ABL1 (0.54) | CDK2GSK3BIRAK4ROCK2CHEK1 | |
| SCHEMBL5654032 | 0.72 | ACVR1 (0.62) | CHEK1BACE1KDRPIM1CDK5 | |
| SCHEMBL1290992 | 0.68 | IRAK4 (0.77) | MAP4K4CLK4CDK2GSK3BIRAK4 | |
| SCHEMBL4855034 | 0.68 | CHEK1 (0.64) | MAP4K4CLK4CDK2GSK3BIRAK4 | |
| SCHEMBL23002820 | 0.67 | MEN1 (0.60) | CDK5PLK4PDPK1EGFRCDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1606268-B1 | 5,10-DIHYDRO-11H-DIBENZO[B,E][1,4]DIAZEPIN-11-ONE AS KINASE INHIBITORS | ABBVIE INC (US) | 2015-05-20 | — | — | EP | disclosed |
| US-7456169-B2 | Heterocyclic kinase inhibitors | ABBOTT LABORATORIES INC. (US) | 2008-11-25 | — | — | US | disclosed |
| US-20070254867-A1 | Heterocyclic Kinase Inhibitors | ABBVIE INC. | 2007-11-01 | — | — | US | disclosed |
| US-20040254159-A1 | Heterocyclic kinase inhibitors | ABBOTT LABORATORIES | 2004-12-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040254159-A1 | Heterocyclic kinase inhibitors | MAP3K20, MAP3K19, MAP3K1 | MAP4K4 26/4885CLK4 701/4885CDK2 19/4885 |
| US-20070254867-A1 | Heterocyclic Kinase Inhibitors | MAP3K20, MAP3K19, MAP4K2 | MAP4K4 35/4885CLK4 652/4885CDK2 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.