Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 13/20 | 0.57 |
| ▸ | PIK3CG | P48736 | 13/20 | 0.57 |
| ▸ | PIK3CA | P42336 | 11/20 | 0.57 |
| ▸ | PIK3CB | P42338 | 9/20 | 0.57 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.42 |
| ▸ | CLK1 | P49759 | 1/20 | 0.42 |
| ▸ | CLK2 | P49760 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.34 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL48521 | 0.83 | PIK3CD (0.47) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL48466 | 0.79 | PIK3CD (0.63) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL2074226 | 0.75 | PIK3CD (0.65) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL28751509 | 0.74 | PIK3CD (0.57) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL48660 | 0.73 | PIK3CG (1.00) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL48835 | 0.72 | PIK3CD (0.81) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL12363422 | 0.71 | PIK3CD (0.80) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL1788763 | 0.71 | PIK3CD (0.51) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL49387 | 0.70 | PIK3CD (0.78) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL28760237 | 0.70 | PIK3CD (0.57) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129541-B2 | 5-phenylthiazole derivatives and use as PI3 kinase inhibitors | NOVARTIS AG (CH) | 2012-03-06 | — | — | US | disclosed |
| US-20100093690-A1 | 5-PHENYLTHIAZOLE DERIVATIVES AND USE AS PI3 KINASE INHIBITORS | BRUCE IAN | 2010-04-15 | — | — | US | disclosed |
| US-7687637-B2 | 5-phenylthiazole derivatives and use as Pi3 kinase inhibitors | NOVARTIS AG (CH) | 2010-03-30 | — | — | US | disclosed |
| CN-100548996-C | 5-phenylthiazole derivatives and their use for the preparation of medicaments | NOVARTIS AG (CH) | 2009-10-14 | — | — | CN | disclosed |
| EP-1689391-B1 | 5-PHENYL-4-METHYL-THIAZOL-2-YL-AMINE DERIVATIVES AS INHIBITORS OF PHOSPHATIDYLINOSITOL 3 KINASE ENZYMES (PI3) FOR THE TREATMENT OF INFLAMMATORY AIRWAY DISEASES | NOVARTIS AG (CH) | 2009-04-22 | — | — | EP | disclosed |
| CN-1639139-A | 5-phenylthiazole derivatives and use as PI3 kinase inhibitors | NOVARTIS AG (CH) | 2005-07-13 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100093690-A1 | 5-PHENYLTHIAZOLE DERIVATIVES AND USE AS PI3 KINASE INHIBITORS | PIK3CA, PIK3R5, PIP5K1B | PIK3CD 4/4885PIK3CG 8/4885PIK3CA 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.