SCHEMBL4852622

SCHEMBL4852622

[O]C1=CC=CSN1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6224411 0.67
SCHEMBL28180618 0.67
SCHEMBL11636007 0.67
SCHEMBL30248 0.65
SCHEMBL4757408 0.65
SCHEMBL11179277 0.65
SCHEMBL11196444 0.64
SCHEMBL4558041 0.62
SCHEMBL31120452 0.62
SCHEMBL31576257 0.62

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080149097-A1 Beta-agonist compounds comprising nitric oxide donor groups and reactive oxygen species scavenger groups and their use in the treatment of respiratory disordersB YISSUM RESEARCH DEVELOPMENT COMPANY OF HEBREW UNIVERSITY OF JERUSALEM (IL) 2008-06-26 US disclosed
US-7378438-B2 Beta-agonist compounds comprising nitric oxide donor groups and reactive oxygen species scavenger groups and their use in the treatment of respiratory disorders YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) 2008-05-27 US disclosed
US-20060258652-A1 Beta-blockers having antioxidant and no-donor activity YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) 2006-11-16 US disclosed
US-20060247216-A1 Steroid compounds comprising superoxide dismutase mimic groups and nitric oxide donor groups, and their use in the preparation of medicaments YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) 2006-11-02 US disclosed
US-20060166894-A1 Ace-inhibitors having antioxidant and no-donor activity YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) 2006-07-27 US disclosed
EP-1503754-B1 BETA-AGONIST COMPOUNDS COMPRISING NITRIC OXIDE DONOR GROUPS AND REACTIVE OXYGEN SPECIES SCAVENGER GROUPS AND THEIR USE IN THE TREATMENT OF RESPIRATORY DISORDERS YISSUM RES DEV CO (IL) 2005-11-23 EP disclosed
US-20050228184-A1 Beta-agonist compounds comprising nitric oxide donor groups and reactive oxygen species scavenger groups and their use in the treatment of respiratory disorders YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) 2005-10-13 US disclosed
EP-1578413-A2 ACE-INHIBITORS HAVING ANTIOXIDANT AND NO-DONOR ACTIVITY Yissum Research Development Company of The Hebrew University of Jerusalem (IL) 2005-09-28 EP disclosed
EP-1562975-A2 STEROID COMPOUNDS COMPRISING SUPEROXIDE DISMUTASE MIMIC GROUPS AND NITRIC OXIDE DONOR GROUPS, AND THEIR USE IN THE PREPARATION OF MEDICAMENTS YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) 2005-08-17 EP disclosed
EP-1503754-A1 BETA-AGONIST COMPOUNDS COMPRISING NITRIC OXIDE DONOR GROUPS AND REACTIVE OXYGEN SPECIES SCAVENGER GROUPS AND THEIR USE IN THE TREATMENT OF RESPIRATORY DISORDERS Yissum Research Development Company, of The Hebrew University of Jerusalem (IL) 2005-02-09 EP disclosed
WO-2004050084-A2 ACE-INHIBITORS HAVING ANTIOXIDANT AND NITRICOXID-DONOR ACTIVITY YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) 2004-06-17 WO disclosed
WO-2004047837-A2 BETA-BLOCKERS HAVING ANTIOXIDANT AND NITRIC OXIDE-DONOR ACTIVITY YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) 2004-06-10 WO disclosed
WO-2004037843-A2 STEROID COMPOUNDS COMPRISING SUPEROXIDE DISMUTASE MIMIC GROUPS AND NITRIC OXIDE DONOR GROUPS, AND THEIR USE IN THE PREPARATION OF MEDICAMENTS YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) 2004-05-06 WO disclosed
WO-2003088961-A1 BETA-AGONIST COMPOUNDS COMPRISING NITRIC OXIDE DONOR GROUPS AND REACTIVE OXYGEN SPECIES SCAVENGER GROUPS AND THEIR USE IN THE TREATMENT OF RESPIRATORY DISORDERS YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) 2003-10-30 WO disclosed