Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 5/20 | 0.75 |
| ▸ | KDR | P35968 | 3/20 | 0.75 |
| ▸ | AURKA | O14965 | 1/20 | 0.75 |
| ▸ | CHEK1 | O14757 | 19/20 | 0.58 |
| ▸ | PIM1 | P11309 | 4/20 | 0.52 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.52 |
| ▸ | TAOK1 | Q7L7X3 | 4/20 | 0.52 |
| ▸ | CDK9 | P50750 | 3/20 | 0.52 |
| ▸ | PRKX | P51817 | 3/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.52 |
| ▸ | GSK3A | P49840 | 3/20 | 0.52 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.52 |
| ▸ | CDK1 | P06493 | 3/20 | 0.52 |
| ▸ | CDK8 | P49336 | 2/20 | 0.52 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.52 |
| ▸ | CDK2 | P24941 | 2/20 | 0.52 |
| ▸ | GSK3B | P49841 | 2/20 | 0.52 |
| ▸ | CAMK2B | Q13554 | 2/20 | 0.52 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.52 |
| ▸ | PBK | Q96KB5 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4856314 | 0.86 | CHEK1 (0.75) | CHEK1 | |
| SCHEMBL4857572 | 0.86 | AURKB (1.00) | AURKBKDRAURKACHEK1PIM1 | |
| SCHEMBL4857283 | 0.84 | AURKA (0.51) | AURKBKDRAURKACHEK1FLT3 | |
| SCHEMBL4849262 | 0.81 | CHEK1 (0.74) | CHEK1 | |
| SCHEMBL4857110 | 0.77 | CHEK1 (0.77) | AURKBKDRAURKACHEK1MAP4K4 | |
| SCHEMBL4857378 | 0.77 | CHEK1 (0.54) | AURKBKDRAURKACHEK1MAP4K4 | |
| SCHEMBL4853284 | 0.75 | CHEK1 (0.54) | AURKBKDRAURKACHEK1MAP4K4 | |
| SCHEMBL4860069 | 0.74 | CHEK1 (1.00) | AURKBKDRAURKACHEK1PIM1 | |
| SCHEMBL4859265 | 0.74 | CHEK1 (0.71) | AURKBKDRAURKACHEK1PRKX | |
| SCHEMBL4856731 | 0.74 | CHEK1 (0.62) | AURKBKDRAURKACHEK1MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1606268-B1 | 5,10-DIHYDRO-11H-DIBENZO[B,E][1,4]DIAZEPIN-11-ONE AS KINASE INHIBITORS | ABBVIE INC (US) | 2015-05-20 | — | — | EP | disclosed |
| US-7456169-B2 | Heterocyclic kinase inhibitors | ABBOTT LABORATORIES INC. (US) | 2008-11-25 | — | — | US | disclosed |
| US-20070254867-A1 | Heterocyclic Kinase Inhibitors | ABBVIE INC. | 2007-11-01 | — | — | US | disclosed |
| US-20040254159-A1 | Heterocyclic kinase inhibitors | ABBOTT LABORATORIES | 2004-12-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040254159-A1 | Heterocyclic kinase inhibitors | MAP3K20, MAP3K19, MAP3K1 | AURKB 196/4885KDR 952/4885AURKA 263/4885 |
| US-20070254867-A1 | Heterocyclic Kinase Inhibitors | MAP3K20, MAP3K19, MAP4K2 | AURKB 165/4885KDR 819/4885AURKA 268/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.