Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 19/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.52 |
| ▸ | CDK2 | P24941 | 2/20 | 0.52 |
| ▸ | GSK3B | P49841 | 2/20 | 0.52 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.52 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.52 |
| ▸ | CDC7 | O00311 | 1/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.52 |
| ▸ | PRKACA | P17612 | 1/20 | 0.52 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.52 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.45 |
| ▸ | MARK3 | P27448 | 2/20 | 0.45 |
| ▸ | AKT1 | P31749 | 2/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.45 |
| ▸ | KIT | P10721 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.45 |
| ▸ | PLK4 | O00444 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4856990 | 0.87 | CHEK1 (0.62) | CHEK1MAP4K4CDK2GSK3BCLK4 | |
| SCHEMBL4857536 | 0.85 | CHEK1 (0.61) | CHEK1MAP4K4CDK2GSK3BCLK4 | |
| SCHEMBL4849596 | 0.81 | CHEK1 (0.66) | CHEK1MAP4K4CDK2GSK3BROCK2 | |
| SCHEMBL4858765 | 0.81 | CHEK1 (0.69) | CHEK1MAP4K4CDK2GSK3BCLK4 | |
| SCHEMBL4858793 | 0.81 | CHEK1 (0.72) | CHEK1CHEK2MARK3AKT1AURKB | |
| SCHEMBL4854940 | 0.81 | CHEK1 (0.67) | CHEK1MAP4K4CDK2GSK3BROCK2 | |
| SCHEMBL4852852 | 0.80 | CHEK1 (0.72) | CHEK1MAP4K4CDK2GSK3BCLK4 | |
| SCHEMBL4852067 | 0.79 | CHEK1 (0.61) | CHEK1MAP4K4CDK2GSK3BROCK2 | |
| SCHEMBL4852284 | 0.79 | CHEK1 (0.66) | CHEK1CHEK2MARK3AKT1AURKB | |
| SCHEMBL4851811 | 0.78 | CHEK1 (0.69) | CHEK1CHEK2MARK3AKT1AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070254867-A1 | Heterocyclic Kinase Inhibitors | ABBVIE INC. | 2007-11-01 | — | — | US | claimed |
| US-7456169-B2 | Heterocyclic kinase inhibitors | ABBOTT LABORATORIES INC. (US) | 2008-11-25 | — | — | US | disclosed |
| US-20070254867-A1 | Heterocyclic Kinase Inhibitors | ABBVIE INC. | 2007-11-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254867-A1 | Heterocyclic Kinase Inhibitors | MAP3K20, MAP3K19, MAP4K2 | CHEK1 38/4885MAP4K4 35/4885CDK2 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.