Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 10/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | USP1 | O94782 | 2/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.32 |
| ▸ | PTGES | O14684 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | PDE5A | O76074 | 1/20 | 0.32 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.32 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CA3 | P07451 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4491828 | 0.84 | CNR1 (0.52) | CNR1CYP2C9CYP3A4CYP2C19NR3C1 | |
| SCHEMBL4868160 | 0.84 | CNR1 (0.44) | CNR1CYP2C9CYP3A4CYP2C19NR3C1 | |
| SCHEMBL4485823 | 0.74 | CNR1 (0.62) | CNR1CYP2C9CYP3A4CYP2C19NR3C1 | |
| SCHEMBL4484236 | 0.73 | HDAC3 (0.41) | CNR1NR3C1MAPTHDAC3LMNA | |
| SCHEMBL4798338 | 0.71 | CNR1 (0.66) | CNR1CYP2C9CYP3A4CYP2C19NR3C1 | |
| SCHEMBL4477029 | 0.68 | CNR1 (0.67) | CNR1CYP2C9CYP3A4CYP2C19NR3C1 | |
| SCHEMBL4469688 | 0.67 | CNR1 (0.59) | CNR1CYP2C9CYP3A4CYP2C19NR3C1 | |
| SCHEMBL4472953 | 0.65 | CNR1 (0.60) | CNR1CYP2C9CYP3A4CYP2C19NR3C1 | |
| SCHEMBL14212433 | 0.65 | CNR1 (0.84) | CNR1CYP2C9CYP3A4CYP2C19NR3C1 | |
| SCHEMBL4492938 | 0.65 | CNR1 (0.75) | CNR1CYP2C9CYP3A4CYP2C19NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1891068-A1 | TRIAZOLOPYRIDINE DERIVATIVES AS CANNABINOID RECEPTOR 1 ANTAGONISTS | Bristol-Myers Squibb Company (US) | 2008-02-27 | — | — | EP | disclosed |
| WO-2006138695-A1 | TRIAZOLOPYRIDINE DERIVATIVES AS CANNABINOID RECEPTOR 1 ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-12-28 | — | — | WO | disclosed |