Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 16/20 | 0.54 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.51 |
| ▸ | PRKX | P51817 | 1/20 | 0.51 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 3/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.39 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.39 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.37 |
| ▸ | GSK3B | P49841 | 3/20 | 0.34 |
| ▸ | CDC7 | O00311 | 2/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.34 |
| ▸ | PRKACA | P17612 | 2/20 | 0.34 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4858995 | 0.93 | CHEK1 (0.53) | CHEK1PDPK1ROCK2PRKXTNK2 | |
| SCHEMBL4854838 | 0.88 | CHEK1 (0.57) | CHEK1PDPK1ROCK2PRKXTNK2 | |
| SCHEMBL4856972 | 0.86 | CHEK1 (0.58) | CHEK1PDPK1ROCK2PRKXTNK2 | |
| SCHEMBL4855001 | 0.85 | CHEK1 (0.52) | CHEK1PDPK1ROCK2PRKXTNK2 | |
| SCHEMBL4854771 | 0.85 | CHEK1 (0.59) | CHEK1PDPK1ROCK2PRKXTNK2 | |
| SCHEMBL4858076 | 0.85 | CHEK1 (0.60) | CHEK1PDPK1ROCK2PRKXTNK2 | |
| SCHEMBL4858594 | 0.84 | CHEK1 (0.69) | CHEK1PDPK1ROCK2PRKXTNK2 | |
| SCHEMBL4857023 | 0.83 | CHEK1 (0.77) | CHEK1PDPK1ROCK2PRKXTNK2 | |
| SCHEMBL4850253 | 0.82 | CHEK1 (0.57) | CHEK1PDPK1ROCK2PRKXTNK2 | |
| SCHEMBL4858873 | 0.80 | CHEK1 (0.67) | CHEK1PDPK1ROCK2PRKXTNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070254867-A1 | Heterocyclic Kinase Inhibitors | ABBVIE INC. | 2007-11-01 | — | — | US | claimed |
| US-7456169-B2 | Heterocyclic kinase inhibitors | ABBOTT LABORATORIES INC. (US) | 2008-11-25 | — | — | US | disclosed |
| US-20070254867-A1 | Heterocyclic Kinase Inhibitors | ABBVIE INC. | 2007-11-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254867-A1 | Heterocyclic Kinase Inhibitors | MAP3K20, MAP3K19, MAP4K2 | CHEK1 38/4885PDPK1 118/4885ROCK2 483/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.