Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 13/20 | 0.56 |
| ▸ | CES1 | P23141 | 2/20 | 0.48 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | TGM2 | P21980 | 1/20 | 0.41 |
| ▸ | PPOX | P50336 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4857329 | 1.00 | CHEK1 (0.56) | CHEK1CES1MAOAMAOBTGM2 | |
| SCHEMBL4848111 | 0.92 | CHEK1 (0.58) | CHEK1CES1MAOAMAOBTGM2 | |
| SCHEMBL4858965 | 0.88 | CHEK1 (0.60) | CHEK1CES1MAOAMAOBTGM2 | |
| SCHEMBL4858414 | 0.82 | CHEK1 (0.60) | CHEK1CES1MAOAMAOBTGM2 | |
| SCHEMBL4855296 | 0.82 | CHEK1 (0.56) | CHEK1CES1MAOAMAOBTGM2 | |
| SCHEMBL4856183 | 0.82 | CHEK1 (0.56) | CHEK1CES1MAOAMAOBTGM2 | |
| SCHEMBL4857592 | 0.81 | CHEK1 (0.52) | CHEK1CES1MAOAMAOBTGM2 | |
| SCHEMBL4852239 | 0.81 | CHEK1 (0.52) | CHEK1CES1MAOAMAOBTGM2 | |
| SCHEMBL4851939 | 0.81 | CHEK1 (0.55) | CHEK1CES1TGM2 | |
| SCHEMBL4847594 | 0.81 | CHEK1 (0.55) | CHEK1CES1MAOAMAOBTGM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7456169-B2 | Heterocyclic kinase inhibitors | ABBOTT LABORATORIES INC. (US) | 2008-11-25 | — | — | US | disclosed |
| US-20070254867-A1 | Heterocyclic Kinase Inhibitors | ABBVIE INC. | 2007-11-01 | — | — | US | disclosed |
| US-20040254159-A1 | Heterocyclic kinase inhibitors | ABBOTT LABORATORIES | 2004-12-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040254159-A1 | Heterocyclic kinase inhibitors | MAP3K20, MAP3K19, MAP3K1 | CHEK1 46/4885CES1 1804/4885MAOA 2117/4885 |
| US-20070254867-A1 | Heterocyclic Kinase Inhibitors | MAP3K20, MAP3K19, MAP4K2 | CHEK1 38/4885CES1 2761/4885MAOA 1994/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.