Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 4/20 | 0.42 |
| ▸ | KIT | P10721 | 3/20 | 0.42 |
| ▸ | FLT3 | P36888 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | TUBB4A | P04350 | 6/20 | 0.36 |
| ▸ | TUBB | P07437 | 6/20 | 0.36 |
| ▸ | TUBA3C | P0DPH7 | 6/20 | 0.36 |
| ▸ | TUBA1B | P68363 | 6/20 | 0.36 |
| ▸ | TUBA4A | P68366 | 6/20 | 0.36 |
| ▸ | TUBB4B | P68371 | 6/20 | 0.36 |
| ▸ | TUBB3 | Q13509 | 6/20 | 0.36 |
| ▸ | TUBB2A | Q13885 | 6/20 | 0.36 |
| ▸ | TUBB8 | Q3ZCM7 | 6/20 | 0.36 |
| ▸ | TUBA3E | Q6PEY2 | 6/20 | 0.36 |
| ▸ | TUBA1A | Q71U36 | 6/20 | 0.36 |
| ▸ | TUBA1C | Q9BQE3 | 6/20 | 0.36 |
| ▸ | TUBB6 | Q9BUF5 | 6/20 | 0.36 |
| ▸ | TUBB2B | Q9BVA1 | 6/20 | 0.36 |
| ▸ | TUBB1 | Q9H4B7 | 6/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4855988 | 1.00 | FYN (0.42) | FYNKITFLT3ABL1NTRK1 | |
| SCHEMBL4865287 | 0.90 | BRD4 (0.39) | FLT3TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL4865283 | 0.90 | BRD4 (0.39) | FLT3TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL4865064 | 0.86 | BRAF (0.44) | FYNKITMAPT | |
| SCHEMBL4866200 | 0.86 | HPGD (0.39) | FYNKITTUBB4ATUBBTUBA3C | |
| SCHEMBL4866188 | 0.86 | HPGD (0.39) | FYNKITTUBB4ATUBBTUBA3C | |
| SCHEMBL4865058 | 0.86 | BRAF (0.44) | FYNKITMAPT | |
| SCHEMBL4867830 | 0.86 | CYP1A1 (0.38) | KITNTRK1MAPT | |
| SCHEMBL4867821 | 0.86 | CYP1A1 (0.38) | KITNTRK1MAPT | |
| SCHEMBL4864178 | 0.86 | EGFR (0.43) | FLT3TUBB4ATUBBTUBA3CTUBA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7452873-B2 | Inhibitors of GSK-3 and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-11-18 | — | — | US | disclosed |
| US-20050222237-A1 | Inhibitors of GSK-3 and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED | 2005-10-06 | — | — | US | disclosed |
| US-6916798-B2 | Inhibitors of GSK-3 and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2005-07-12 | — | — | US | disclosed |
| US-20040024040-A1 | Inhibitors of GSK-3 and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED | 2004-02-05 | — | — | US | disclosed |
| WO-2003011287-A1 | PYRAZOLON DERIVATIVES AS INHIBITORS OF GSK-3 | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2003-02-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040024040-A1 | Inhibitors of GSK-3 and uses thereof | GSK3B, AURKC, GSK3A | FYN 1415/4885KIT 847/4885FLT3 1304/4885 |
| US-20050222237-A1 | Inhibitors of GSK-3 and uses thereof | GSK3B, AURKC, GSK3A | FYN 1415/4885KIT 847/4885FLT3 1304/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.