Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AIMP2 | Q13155 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 4/20 | 0.38 |
| ▸ | JAK3 | P52333 | 4/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 2/20 | 0.38 |
| ▸ | BCR | P11274 | 2/20 | 0.38 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.37 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.37 |
| ▸ | SYK | P43405 | 4/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | CLK1 | P49759 | 1/20 | 0.34 |
| ▸ | CLK2 | P49760 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.34 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4751809 | 0.85 | ABL1 (0.42) | AIMP2JAK2JAK3ABL1BCR | |
| SCHEMBL14023511 | 0.84 | ABL1 (0.40) | AIMP2JAK2JAK3CDK2FLT3 | |
| SCHEMBL1098407 | 0.84 | ABL1 (0.43) | AIMP2JAK2JAK3ABL1BCR | |
| SCHEMBL1108273 | 0.83 | AIMP2 (0.47) | AIMP2JAK2JAK3CDK2ABL1 | |
| SCHEMBL4749275 | 0.82 | ABL1 (0.39) | AIMP2JAK2JAK3ABL1BCR | |
| SCHEMBL1098894 | 0.82 | SYK (0.40) | AIMP2JAK2JAK3FLT3ABL1 | |
| SCHEMBL1098622 | 0.81 | ABL1 (0.40) | AIMP2JAK2JAK3CDK2FLT3 | |
| SCHEMBL14845405 | 0.81 | ABL1 (0.41) | AIMP2JAK2JAK3CDK2ABL1 | |
| SCHEMBL14022857 | 0.81 | IGF1R (0.40) | AIMP2JAK2JAK3CDK2ABL1 | |
| SCHEMBL1099020 | 0.80 | JAK2 (0.43) | AIMP2JAK2JAK3CDK2FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008060248-A1 | INDOLE SUSTITUTED PYRIMIDINES AND USE THEREOF IN THE TREATMENT OF CANCER | S*BIO PTE LTD. (SG) | 2008-05-22 | — | — | WO | disclosed |