Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.32 |
| ▸ | ATR | Q13535 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4902397 | 0.90 | AKT1 (0.30) | CHEK1CHEK2 | |
| SCHEMBL4876491 | 0.87 | KDM4E (0.36) | CHEK1CHEK2PTGS2PTGS1ATR | |
| SCHEMBL4854572 | 0.85 | PTGS1 (0.33) | CHEK2PTGS2PTGS1 | |
| SCHEMBL4851752 | 0.84 | CYP2E1 (0.36) | PTGS2PTGS1 | |
| SCHEMBL4845511 | 0.84 | TLR7 (0.38) | CHEK2PTGS2PTGS1 | |
| SCHEMBL4812977 | 0.83 | PTGS1 (0.34) | CHEK2PTGS2PTGS1 | |
| SCHEMBL4853177 | 0.82 | PTGS1 (0.38) | PTGS2PTGS1 | |
| SCHEMBL4867771 | 0.79 | PTGS1 (0.31) | PTGS2PTGS1 | |
| SCHEMBL14194774 | 0.77 | PDE10A (0.39) | PTGS2 | |
| SCHEMBL4869091 | 0.72 | PDE10A (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080090834-A1 | SELECTIVE AZOLE PDE10A INHIBITOR COMPOUNDS | PFIZER INC | 2008-04-17 | — | — | US | disclosed |
| WO-2008004117-A1 | SELECTIVE AZOLE PDE10A INHIBITOR COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2008-01-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080090834-A1 | SELECTIVE AZOLE PDE10A INHIBITOR COMPOUNDS | PDE5A, PDE3B, PDE12 | CHEK1 3715/4885CHEK2 3268/4885PTGS2 854/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.