Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MC4R | P32245 | 3/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.37 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13313000 | 0.84 | GAA (0.54) | MAPTSMN1; SMN2ALDH1A1HTTFFAR1 | |
| SCHEMBL24933018 | 0.79 | FFAR1 (0.53) | KCNH2SMN1; SMN2ALDH1A1HTTFFAR1 | |
| SCHEMBL4851905 | 0.76 | SMN1; SMN2 (0.39) | MAPTTHRBSMN1; SMN2ALDH1A1HTT | |
| SCHEMBL4856194 | 0.71 | TSHR (0.51) | MAPTTHRBSMN1; SMN2ALDH1A1HTT | |
| SCHEMBL5252344 | 0.71 | KDM4E (0.45) | MAPTSMN1; SMN2ALDH1A1HTTKDM4E | |
| SCHEMBL8270922 | 0.70 | FFAR1 (0.40) | KCNH2SMN1; SMN2FFAR1 | |
| SCHEMBL4572874 | 0.69 | KDM4E (0.59) | MAPTSMN1; SMN2ALDH1A1KDM4ETDP1 | |
| SCHEMBL1447864 | 0.69 | SLC6A4 (0.59) | SMN1; SMN2ALDH1A1KDM4ESLC6A4KMT2A | |
| SCHEMBL30504080 | 0.69 | SLC6A4 (0.59) | SMN1; SMN2ALDH1A1KDM4ESLC6A4KMT2A | |
| SCHEMBL741492 | 0.68 | SMN1; SMN2 (0.50) | MAPTSMN1; SMN2ALDH1A1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7456169-B2 | Heterocyclic kinase inhibitors | ABBOTT LABORATORIES INC. (US) | 2008-11-25 | — | — | US | disclosed |
| US-20070254867-A1 | Heterocyclic Kinase Inhibitors | ABBVIE INC. | 2007-11-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254867-A1 | Heterocyclic Kinase Inhibitors | MAP3K20, MAP3K19, MAP4K2 | MAPT 3753/4885THRB 1953/4885PTGER1 1996/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.