SCHEMBL485889

SCHEMBL485889

OC(CCl)CCl.OCC(Cl)CCl

nearest known ligand 0.77

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.77
TDP1 Q9NUW8 2/20 0.77
TP53 P04637 1/20 0.77
CA1 P00915 2/20 0.41
CA2 P00918 2/20 0.41
CA9 Q16790 1/20 0.41
LMNA P02545 3/20 0.37
ALDH1A1 P00352 2/20 0.37
L3MBTL1 Q9Y468 1/20 0.33
THRB P10828 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7990290 0.92 TSHR (0.72) TSHRTDP1TP53CA1CA2
SCHEMBL7521154 0.87
SCHEMBL19653 0.87
SCHEMBL7522663 0.87
Water SCHEMBL11799334 0.84
1,2,3-Trichloropropane SCHEMBL6690126 0.84 TSHR (0.93) TSHRTDP1TP53LMNAALDH1A1
SCHEMBL27501367 0.84
1,2-Dichloroethane SCHEMBL3263338 0.81 TSHR (0.87) TSHRTDP1TP53LMNAALDH1A1
1,2,3-Trichloropropane SCHEMBL2196953 0.79 TSHR (0.61) TSHRTDP1TP53CA1CA2
1,2,3-Trichloropropane SCHEMBL1936443 0.79 TSHR (0.61) TSHRTDP1TP53CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130274488-A1 PROCESS FOR PREPARING AN EPOXIDE SOLVAY (BE) 2013-10-17 US disclosed
US-8519198-B2 Method for making an epoxide SOLVAY (SOCIETE ANONYME) (BE) 2013-08-27 US disclosed
US-8420871-B2 Process for producing an organic compound SOLVAY (SOCIETE ANONYME) (BE) 2013-04-16 US disclosed
US-20120199786-A1 METHOD FOR MAKING AN EPOXIDE SOLVAY (SOCIETE ANONYME) (BE) 2012-08-09 US disclosed
US-8173823-B2 preparing an epoxide, wherein halogenated ketones are formed as by-products and there is at least one treatment intended to remove at least part of the halogenated ketones formed. Solvay (Société Anonyme) (BE) 2012-05-08 US disclosed
US-8106245-B2 preparing an epoxide, wherein halogenated ketones are formed as by-products and there is at least one treatment intended to remove at least part of the halogenated ketones formed. Solvay (Société Anonyme) (BE) 2012-01-31 US disclosed
US-20120010420-A1 PROCESS FOR PRODUCING AN ORGANIC COMPOUND SOLVAY (SOCIETE ANONYME) (BE) 2012-01-12 US disclosed
US-8067645-B2 preparing an epoxide, wherein halogenated ketones are formed as by-products and there is at least one treatment intended to remove at least part of the halogenated ketones formed. SOLVAY (SOCIETE ANONYME) (BE) 2011-11-29 US disclosed
EP-1663924-B1 METHOD OF PREPARING DICHLOROPROPANOLS FROM GLYCERINE SPOLEK (CZ) 2011-10-26 EP disclosed
US-20080207930-A1 Process For Producing a Chlorhydrin From a Multihydroxylated Aliphatic Hydrocarbon and/or Ester Thereof in the presence of Metal Salts Gilbeau, Patrick 2008-08-28 US disclosed
US-20080194850-A1 Method for Making an Epoxide Starting with a Polyhydroxylated Aliphatic Hydrocarbon and a Chlorinating Agent SOLVAY (SOCIETE ANONYME) (BE) 2008-08-14 US disclosed
US-20080154050-A1 Method for Making an Epoxide Gilbeau, Patrick 2008-06-26 US disclosed
EP-1885706-A2 METHOD FOR MAKING AN EPOXIDE STARTING WITH A POLYHYDROXYLATED ALIPHATIC HYDROCARBON AND A CHLORINATING AGENT SOLVAY (SOCIETE ANOMYME) (BE) 2008-02-13 EP disclosed
WO-2006100318-A9 METHOD FOR MAKING AN EPOXIDE STARTING WITH A POLYHYDROXYLATED ALIPHATIC HYDROCARBON AND A CHLORINATING AGENT SOLVAY (BE) 2006-11-16 WO disclosed
WO-2006100318-A2 METHOD FOR MAKING AN EPOXIDE STARTING WITH A POLYHYDROXYLATED ALIPHATIC HYDROCARBON AND A CHLORINATING AGENT Solvay (Société Anonyme) (BE) 2006-09-28 WO disclosed