Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.43 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MGAM | O43451 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SI | P14410 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4857474 | 0.90 | DYRK1A (0.41) | CYP19A1ALDH1A1HTTSMN1; SMN2DYRK1A | |
| SCHEMBL4855301 | 0.85 | DYRK1A (0.43) | CYP19A1ALDH1A1HTTSMN1; SMN2DYRK1A | |
| SCHEMBL4857053 | 0.81 | DYRK1A (0.43) | CYP19A1DYRK1AKCNH2NFATC1GSK3B | |
| SCHEMBL29801631 | 0.80 | DYRK1A (0.66) | CYP19A1ALDH1A1SMN1; SMN2DYRK1AKCNH2 | |
| SCHEMBL4857531 | 0.80 | DYRK1A (0.66) | CYP19A1ALDH1A1SMN1; SMN2DYRK1AKCNH2 | |
| SCHEMBL4857216 | 0.79 | DYRK1A (0.45) | CYP19A1DYRK1AKCNH2NFATC1GSK3B | |
| SCHEMBL4848675 | 0.78 | DYRK1A (0.42) | CYP19A1ALDH1A1DYRK1AKCNH2NFATC1 | |
| SCHEMBL4857049 | 0.78 | DYRK1A (0.42) | CYP19A1DYRK1AKCNH2NFATC1GSK3B | |
| SCHEMBL4856748 | 0.78 | DYRK1A (0.48) | CYP19A1DYRK1AKCNH2NFATC1GSK3B | |
| SCHEMBL4849658 | 0.78 | DYRK1A (0.67) | CYP19A1ALDH1A1HTTSMN1; SMN2DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7456169-B2 | Heterocyclic kinase inhibitors | ABBOTT LABORATORIES INC. (US) | 2008-11-25 | — | — | US | disclosed |
| US-20070254867-A1 | Heterocyclic Kinase Inhibitors | ABBVIE INC. | 2007-11-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254867-A1 | Heterocyclic Kinase Inhibitors | MAP3K20, MAP3K19, MAP4K2 | CYP19A1 1766/4885ALDH1A1 3257/4885HTT 4566/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.