Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 4/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.35 |
| ▸ | WNT1 | P04628 | 1/20 | 0.35 |
| ▸ | CLK2 | P49760 | 1/20 | 0.35 |
| ▸ | CLK3 | P49761 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL486392 | 0.97 | MEN1 (0.39) | NAMPTMAP4K4MEN1KMT2APDE4B | |
| SCHEMBL486297 | 0.96 | NAMPT (0.41) | NAMPTMAP4K4TLR7MEN1KMT2A | |
| SCHEMBL485906 | 0.90 | MEN1 (0.40) | NAMPTMEN1KMT2APDE4BADORA2A | |
| SCHEMBL486210 | 0.87 | NAMPT (0.51) | NAMPTMEN1KMT2APDE4BADORA2A | |
| SCHEMBL3048503 | 0.87 | NAMPT (0.50) | NAMPTKCNH2EPHX2SCN9A | |
| SCHEMBL3044891 | 0.87 | NAMPT (0.48) | NAMPTCHRNA7KCNH2EPHX2 | |
| SCHEMBL486031 | 0.87 | MAP4K4 (0.40) | MAP4K4TLR7MEN1KMT2ACHRNA7 | |
| SCHEMBL485903 | 0.87 | PIK3CA (0.41) | NAMPTMAP4K4MEN1KMT2APDPK1 | |
| SCHEMBL485908 | 0.87 | PIK3CA (0.41) | NAMPTMAP4K4MEN1KMT2APDPK1 | |
| SCHEMBL485853 | 0.86 | PIK3CA (0.41) | NAMPTMAP4K4MEN1KMT2APDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411368-A1 | NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF AS ANTICANCER DRUGS | SANOFI (FR) | 2012-02-01 | — | — | EP | claimed |
| WO-2010109122-A1 | NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF AS ANTICANCER DRUGS | SANOFI-AVENTIS (FR) | 2010-09-30 | — | — | WO | claimed |