Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Silver. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.95 |
| ▸ | CA2 | P00918 | 2/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.52 |
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.50 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.48 |
| ▸ | FDPS | P14324 | 4/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.44 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Silver SCHEMBL17797181 | 0.98 | CA1 (0.91) | CA1CA2NFKB1GPR84ACE2 | |
| Silver SCHEMBL17797179 | 0.98 | CA1 (0.91) | CA1CA2NFKB1GPR84ACE2 | |
| Silver SCHEMBL17797175 | 0.98 | CA1 (0.91) | CA1CA2NFKB1GPR84ACE2 | |
| SCHEMBL15022052 | 0.98 | CA1 (1.00) | CA1CA2NFKB1GPR84ACE2 | |
| SCHEMBL15022951 | 0.95 | CA1 (0.95) | CA1CA2NFKB1GPR84ACE2 | |
| Zinc Ion SCHEMBL8412500 | 0.95 | CA1 (0.95) | CA1CA2NFKB1GPR84ACE2 | |
| Potassium Ion SCHEMBL29948033 | 0.95 | CA1 (0.95) | CA1CA2NFKB1GPR84ACE2 | |
| SCHEMBL15022175 | 0.95 | CA1 (0.95) | CA1CA2NFKB1GPR84ACE2 | |
| SCHEMBL8678860 | 0.95 | CA1 (1.00) | CA1CA2NFKB1GPR84ACE2 | |
| SCHEMBL15022016 | 0.95 | CA1 (0.95) | CA1CA2NFKB1GPR84ACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2610248-B1 | METHOD FOR PRODUCING PHENYL-SUBSTITUTED HETEROCYCLIC DERIVATIVE BY MEANS OF COUPLING METHOD USING A PALLADIUM COMPOUND | TEIJIN PHARMA LTD (JP) | 2016-06-08 | — | — | EP | claimed |
| US-7429341-B2 | Electroconductive composition, method for producing electroconductive film, and electroconductive film | THE YOKOHAMA RUBBER CO., LTD. (JP) | 2008-09-30 | — | — | US | disclosed |
| US-20070235695-A1 | ELECTROCONDUCTIVE COMPOSITION, METHOD FOR PRODUCING ELECTROCONDUCTIVE FILM, AND ELECTROCONDUCTIVE FILM | THE YOKOHAMA RUBBER CO., LTD. (JP) | 2007-10-11 | — | — | US | disclosed |