Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 7/20 | 0.36 |
| ▸ | C5AR1 | P21730 | 2/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 3/20 | 0.34 |
| ▸ | PARP15 | Q460N3 | 2/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.34 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.32 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.32 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1327343 | 0.85 | PARP10 (0.41) | IRAK4C5AR1PARP10PARP15MKNK1 | |
| SCHEMBL1327355 | 0.85 | AKR1C3 (0.40) | IRAK4C5AR1PARP10PARP15MKNK1 | |
| SCHEMBL1327776 | 0.85 | C5AR1 (0.38) | C5AR1FFAR4 | |
| SCHEMBL1328648 | 0.82 | C5AR1 (0.38) | C5AR1FFAR4 | |
| SCHEMBL1330117 | 0.81 | C5AR1 (0.41) | C5AR1 | |
| SCHEMBL1329563 | 0.81 | C5AR1 (0.37) | C5AR1S1PR1 | |
| SCHEMBL2142265 | 0.80 | C5AR1 (0.41) | C5AR1S1PR1FFAR4 | |
| SCHEMBL1328339 | 0.80 | C5AR1 (0.35) | C5AR1S1PR1FFAR4 | |
| SCHEMBL1329407 | 0.80 | C5AR1 (0.38) | C5AR1 | |
| SCHEMBL1328473 | 0.80 | C5AR1 (0.38) | C5AR1S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7342115-B2 | Binding antagonist and arylpyridine for antiinflammatory agents, cardiovascular disorders and antagonist or agonist and for immunology | NEUROGEN CORPORATION (US) | 2008-03-11 | — | — | US | disclosed |