Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 5/20 | 0.47 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL485710 | 0.81 | MRGPRX4 (0.56) | CRHR1MRGPRX4DRD4KMT2ACNR1 | |
| SCHEMBL486088 | 0.79 | MRGPRX4 (0.56) | CRHR1MRGPRX4DRD4KMT2ACNR1 | |
| Formic Acid SCHEMBL27693269 | 0.77 | MRGPRX4 (0.54) | CRHR1MRGPRX4DRD4KMT2ACNR1 | |
| SCHEMBL485826 | 0.76 | MRGPRX4 (0.51) | CRHR1MRGPRX4MAPTLMNAPOLB | |
| SCHEMBL485738 | 0.76 | MRGPRX4 (0.51) | CRHR1MRGPRX4MAPTDRD4LMNA | |
| Bicarbonate SCHEMBL485873 | 0.75 | MRGPRX4 (0.49) | CRHR1MRGPRX4MAPTLMNAPOLB | |
| Formic Acid SCHEMBL27693274 | 0.73 | MAPT (0.44) | CRHR1MAPTDRD4CNR1CNR2 | |
| Formic Acid SCHEMBL27693450 | 0.73 | MRGPRX4 (0.49) | CRHR1MRGPRX4MAPTDRD4LMNA | |
| Formic Acid SCHEMBL27693419 | 0.73 | MRGPRX4 (0.49) | CRHR1MRGPRX4MAPTDRD4LMNA | |
| SCHEMBL485840 | 0.71 | MRGPRX4 (0.47) | MRGPRX4GAAKMT2ACNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836158-B1 | FUSED BICYCLIC CARBOXAMIDE DERIVATIVES FOR USE AS CXCR2 INHIBITORS IN THE TREATMENT OF INFLAMMATION | SANOFI AVENTIS DEUTSCHLAND (DE) | 2012-02-01 | — | — | EP | claimed |