Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 7/20 | 0.51 |
| ▸ | TAS2R8 | Q9NYW2 | 6/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3729601 | 0.87 | IGF1R (0.49) | IGF1RTAS2R8HDAC1HDAC6PPARG | |
| SCHEMBL19410409 | 0.83 | IGF1R (0.46) | IGF1RTAS2R8HDAC1HDAC6PPARG | |
| SCHEMBL19410365 | 0.83 | IGF1R (0.49) | IGF1RTAS2R8HDAC1HDAC6LMNA | |
| SCHEMBL4855706 | 0.77 | IGF1R (0.50) | IGF1RTAS2R8HDAC1HDAC6 | |
| SCHEMBL19410393 | 0.72 | IGF1R (0.55) | IGF1RTAS2R8HDAC1HDAC6 | |
| SCHEMBL13039129 | 0.72 | IGF1R (0.67) | IGF1RTAS2R8 | |
| SCHEMBL2938337 | 0.72 | IGF1R (0.54) | IGF1RTAS2R8PPARGPPARDPPARA | |
| SCHEMBL13039186 | 0.71 | IGF1R (0.68) | IGF1RTAS2R8 | |
| SCHEMBL19410403 | 0.70 | IGF1R (0.44) | IGF1RTAS2R8HDAC1HDAC6 | |
| SCHEMBL19410404 | 0.70 | IGF1R (0.55) | IGF1RTAS2R8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7354933-B2 | Protein kinase inhibitors; antitumor agents; such as 5-methyl-1-quinol-4-ylmethyl-3-(4-trifluoromethanesulfonylphenyl)imidazolidine-2,4-dione trifluoroacetate | AVENTIS PHARMA SA (FR) | 2008-04-08 | — | — | US | disclosed |