Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Dl-Phenylalanine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 known ✓ | P0DMS8 | 1/20 | 0.51 |
| ▸ | SLC7A5 | Q01650 | 4/20 | 0.85 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.85 |
| ▸ | ALPI | P09923 | 1/20 | 0.85 |
| ▸ | PKM | P14618 | 1/20 | 0.85 |
| ▸ | XIAP | P98170 | 1/20 | 0.85 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.61 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.61 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.61 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.61 |
| ▸ | LTA4H | P09960 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.53 |
| ▸ | CPA1 | P15085 | 2/20 | 0.52 |
| ▸ | CPB1 | P15086 | 1/20 | 0.52 |
| ▸ | CPA3 | P15088 | 1/20 | 0.52 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dl-Phenylalanine SCHEMBL1637917 | 1.00 | SLC7A5 (0.85) | SLC7A5PTGS1ALPIPKMXIAP | |
| Phenylalanine SCHEMBL1011892 | 1.00 | SLC7A5 (0.85) | SLC7A5PTGS1ALPIPKMXIAP | |
| D-Phenylalanine SCHEMBL1537448 | 1.00 | SLC7A5 (0.85) | SLC7A5PTGS1ALPIPKMXIAP | |
| Phenylalanine SCHEMBL3496164 | 1.00 | SLC7A5 (0.85) | SLC7A5PTGS1ALPIPKMXIAP | |
| Phenylalanine SCHEMBL2679075 | 1.00 | SLC7A5 (0.85) | SLC7A5PTGS1ALPIPKMXIAP | |
| Dl-Phenylalanine SCHEMBL9650016 | 1.00 | SLC7A5 (0.85) | SLC7A5PTGS1ALPIPKMXIAP | |
| Phenylalanine SCHEMBL1675272 | 1.00 | SLC7A5 (0.85) | SLC7A5PTGS1ALPIPKMXIAP | |
| Phenylalanine SCHEMBL218898 | 1.00 | SLC7A5 (0.85) | SLC7A5PTGS1ALPIPKMXIAP | |
| Dl-Phenylalanine SCHEMBL21816915 | 1.00 | SLC7A5 (0.85) | SLC7A5PTGS1ALPIPKMXIAP | |
| Dl-Phenylalanine SCHEMBL27579186 | 1.00 | SLC7A5 (0.85) | SLC7A5PTGS1ALPIPKMXIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230357807-A1 | CATALYTICALLY ACTIVE PROTEIN FOAMS, AND METHOD FOR PRODUCING SAME | KARLSRUHER INSTITUT FUER TECHNOLOGIE (DE) | 2023-11-09 | — | — | US | disclosed |
| EP-4188942-A1 | CATALYTICALLY ACTIVE PROTEIN FOAMS, AND METHOD FOR PRODUCING SAME | Karlsruher Institut für Technologie (DE) | 2023-06-07 | — | — | EP | disclosed |
| US-7321022-B2 | Electrostatic layer-by-layer self assembly; exposing film to an oxidizing or reducing agent; alternating layers of oppositely charged polypeptides; 1st layer polypeptide contains sulfhydryl-containing amino acid; 2nd layer polypeptide has two amino acid sequences joined by a glycine a proline linker. | LOUISIANA TECH UNIVERSITY FOUNDATION, INC. (US) | 2008-01-22 | — | — | US | disclosed |
| US-20070077275-A1 | Multilayer films, coatings, and microcapsules comprising polypeptides | LOUISIANA TECH UNIVERSITY FOUNDATION, INC. | 2007-04-05 | — | — | US | disclosed |
| US-20060147543-A1 | Method for controlling stability of nanofabricated polypeptide multilayer films, coatings, and microcapsules | HAYNIE DONALD T | 2006-07-06 | — | — | US | disclosed |
| US-6066462-A | ADDING BIOTINYLATED PEPTIDE SUBSTRATE TO SOLUTION CONTAINING SELECTED ENZYME, INCUBATING TO FORM PHOSPHORYLATED PRODUCT, BINDING PRODUCT TO BIOTIN-BINDING MATRIX, DETECTING THE PRODUCT AND THUS MEASURING THE ACTIVITY OF ENZYME | PROMEGA CORPORATION (US) | 2000-05-23 | — | — | US | disclosed |
| US-5981580-A | IN WHICH THE CARBOXY-TERMINUS HAS BEEN MODIFIED TO FORM VARIOUS AMIDES, ESTERS, KETONES, ALCOHOLS, ALCOHOL ESTERS AND NITRITES THEREOF, AND ARE USEFUL AS SUBSTRATES FOR N-MYRISTOYLTRANSFERASE (NMT) AND/OR ITS ACYL COENZYME | G. D. SEARLE & CO. (US) | 1999-11-09 | — | — | US | disclosed |
| WO-1999050229-A1 | FATTY ACID ANALOGS AND PRODRUGS | G.D. SEARLE & CO. (US) | 1999-10-07 | — | — | WO | disclosed |
| US-5545718-A | Synthetic peptides of the conjugate of ubiquitine and H2A histone | PASTEUR SANOFI DIAGNOSTICS (FR) | 1996-08-13 | — | — | US | disclosed |
| US-5427958-A | Detecting presence of autoantibodies in biological fluids; forming peptide complexes; in vitro; diagnosing lupus, autoimmune diseases | PASTEUR SANOFI DIAGNOSTICS (FR) | 1995-06-27 | — | — | US | disclosed |
| US-5057495-A | Hypotensive agents, diuretics | QUEEN'S UNIVERSITY AT KINGSTON (CA) | 1991-10-15 | — | — | US | disclosed |
| EP-0423301-A1 | SYNTHETIC PEPTIDES OF THE CONJUGATE OF UBIQUITINE AND HISTONE H2A. | NEOSYSTEM SA (FR) | 1991-04-24 | — | — | EP | disclosed |
| WO-1990012806-A1 | SYNTHETIC PEPTIDES OF THE CONJUGATE OF UBIQUITINE AND HISTONE H2A | NEOSYSTEM S.A. (FR) | 1990-11-01 | — | — | WO | disclosed |