⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL262159 | 0.81 | — | — | |
| SCHEMBL650952 | 0.81 | — | — | |
| SCHEMBL15766660 | 0.78 | — | — | |
| SCHEMBL1019048 | 0.74 | — | — | |
| Benzene SCHEMBL28151552 | 0.73 | TSHR (0.32) | — | |
| SCHEMBL15766965 | 0.72 | TSHR (0.39) | — | |
| SCHEMBL11396254 | 0.71 | MAPT (0.41) | — | |
| SCHEMBL3028967 | 0.71 | — | — | |
| SCHEMBL9354540 | 0.71 | — | — | |
| SCHEMBL3027063 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0167449-B1 | NEW GANGLIOSIDE DERIVATIVES | FIDIA S.p.A. (IT) | 1990-11-28 | — | — | EP | claimed |
| EP-0167449-A2 | New ganglioside derivatives | FIDIA S.p.A. (IT) | 1986-01-08 | — | — | EP | claimed |
| US-9040516-B2 | Uracil derivative and use thereof for medical purposes | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2015-05-26 | — | — | US | disclosed |
| US-20140179670-A1 | URACIL DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2014-06-26 | — | — | US | disclosed |
| EP-2740728-A1 | URACIL DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES | Dainippon Sumitomo Pharma Co., Ltd. (JP) | 2014-06-11 | — | — | EP | disclosed |
| US-7332515-B2 | Indole-amid derivatives which possess glycogen phosphorylase inhibitory activity | ASTRAZENECA AB (SE) | 2008-02-19 | — | — | US | disclosed |
| US-20070123528-A1 | INDOLE-AMID DERIVATIVES WHICH POSSESS GLYCOGEN PHOSPHORYLASE INHIBITORY ACTIVITY | ASTRAZENECA AB (SE) | 2007-05-31 | — | — | US | disclosed |
| US-7166636-B2 | Type 2 diabetes, insulin resistance, syndrome X, hyperinsulinemia, or hyperglucagonemia; methyl (S)-5-{1-[(5-chloro-1H-indol-2-ylcarbonyl)amino]-2-phenylethyl}oxazole-4-carboxylate; amidation by reacting the 2-carboxyindole and a 1,2-diphenylethylamine | ASTRAZENECA AB (SE) | 2007-01-23 | — | — | US | disclosed |
| US-20050130963-A1 | Indole-amid derivatives which possess glycogen phosphorylase inhibitory activity | ASTRAZENECA AB (SE) | 2005-06-16 | — | — | US | disclosed |
| EP-1492788-A1 | INDOLE-AMID DERIVATIVES WHICH POSSESS GLYCOGEN PHOSPHORYLASE INHIBITORY ACTIVITY | AstraZeneca AB (SE) | 2005-01-05 | — | — | EP | disclosed |
| EP-1284267-B1 | TRIAZOLE COMPOUNDS HAVING AMIDE LINKAGE | SANKYO CO (JP) | 2004-12-15 | — | — | EP | disclosed |
| WO-2003074517-A1 | INDOLE-AMID DERIVATIVES WHICH POSSESS GLYCOGEN PHOSPHORYLASE INHIBITORY ACTIVITY | ASTRAZENECA AB (SE) | 2003-09-12 | — | — | WO | disclosed |
| EP-1284267-A1 | TRIAZOLE COMPOUNDS HAVING AMIDE LINKAGE | Sankyo Company, Limited (JP) | 2003-02-19 | — | — | EP | disclosed |
| US-6008160-A | Substituted 1-amino-3-phenyluracil derivatives, their preparation and their use as herbicides | BAYER AKTIENGESELLSCHAFT (DE) | 1999-12-28 | — | — | US | disclosed |
| US-5965738-A | Process for producing N-biphenylmethylthiadiazoline derivative or salt thereof and intermediate for producing the same | WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) | 1999-10-12 | — | — | US | disclosed |
| EP-0851861-A1 | SUBSTITUTED 1-AMINO-3-PHENYLURACIL DERIVATIVES, THEIR PREPARATION AND THEIR USE AS HERBICIDES | BAYER AG (DE) | 1998-07-08 | — | — | EP | disclosed |
| US-5654322-A | HYPOTENSIVE AGENTS, CEREBRAL APOPLEXY | WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) | 1997-08-05 | — | — | US | disclosed |
| EP-0782996-A1 | PROCESS FOR PRODUCING N-BIPHENYLMETHYLTHIADIAZOLINE DERIVATIVE OR SALT THEREOF AND INTERMEDIATE FOR PRODUCING THE SAME | WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) | 1997-07-09 | — | — | EP | disclosed |
| WO-1997009319-A1 | SUBSTITUTED 1-AMINO-3-PHENYLURACIL DERIVATIVES, THEIR PREPARATION AND THEIR USE AS HERBICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 1997-03-13 | — | — | WO | disclosed |
| EP-0656355-A1 | BIPHENYLMETHANE DERIVATIVE AND MEDICINE CONTAINING THE SAME | WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) | 1995-06-07 | — | — | EP | disclosed |