Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 2/20 | 0.41 |
| ▸ | ATR | Q13535 | 4/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1542512 | 0.74 | CHRNA7 (0.67) | CHRNA7CHRM2CHRM1 | |
| SCHEMBL15786890 | 0.71 | CHRM2 (0.48) | CHRNA7ATRCHRM2CHRM4CHRM5 | |
| SCHEMBL15786891 | 0.71 | CHRM2 (0.48) | CHRNA7ATRCHRM2CHRM4CHRM5 | |
| SCHEMBL15786892 | 0.71 | CHRM2 (0.48) | CHRNA7ATRCHRM2CHRM4CHRM5 | |
| SCHEMBL5706620 | 0.71 | CHRM2 (0.42) | CHRNA7CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL5706619 | 0.70 | CHRNA7 (0.60) | CHRNA7CHRM2CHRM1 | |
| SCHEMBL5408169 | 0.68 | CHRNA7 (0.55) | CHRNA7CHRM1 | |
| SCHEMBL5420826 | 0.68 | CHRNA7 (0.55) | CHRNA7CHRM1 | |
| Hydrochloric Acid SCHEMBL5430453 | 0.67 | CHRNA7 (0.54) | CHRNA7 | |
| SCHEMBL5416196 | 0.67 | CHRNA7 (0.51) | CHRNA7CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1896469-A2 | FUSED BICYCLOHETEROCYCLE SUBSTITUTED QUINUCLIDINE DERIVATIVES | ABBOTT LABORATORIES (US) | 2008-03-12 | — | — | EP | disclosed |
| WO-2007018738-A2 | FUSED BICYCLOHETEROCYCLE SUBSTITUTED QUINUCLIDINE DERIVATIVES | ABBOTT LABORATORIES (US) | 2007-02-15 | — | — | WO | disclosed |