SCHEMBL486309

SCHEMBL486309

O=C(O)c1cncc(Cl)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 5/20 1.00
KDM4E B2RXH2 3/20 0.57
ALDH1A1 P00352 3/20 0.57
MEN1 O00255 2/20 0.57
KMT2A Q03164 2/20 0.57
POLB P06746 1/20 0.57
LMNA P02545 1/20 0.57
DDO Q99489 1/20 0.57
TPMT P51580 1/20 0.56
HCAR1 Q9BXC0 1/20 0.48
CYP2C9 P11712 1/20 0.47
CYP2C19 P33261 1/20 0.47
SMYD3 Q9H7B4 1/20 0.46
MKNK1 Q9BUB5 2/20 0.46
MKNK2 Q9HBH9 2/20 0.46
ALOX15 P16050 1/20 0.44
TSHR P16473 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29944817 1.00 HCAR2 (1.00) HCAR2KDM4EALDH1A1MEN1KMT2A
Hydrochloric Acid SCHEMBL10401123 0.98 HCAR2 (0.96) HCAR2KDM4EALDH1A1MEN1KMT2A
SCHEMBL28695687 0.98 HCAR2 (0.96) HCAR2KDM4EALDH1A1MEN1KMT2A
Hydrazine SCHEMBL27966471 0.96 HCAR2 (0.92) HCAR2KDM4EALDH1A1MEN1KMT2A
Nitrous Acid SCHEMBL28106100 0.92 HCAR2 (0.85) HCAR2KDM4EALDH1A1MEN1KMT2A
SCHEMBL51830 0.83 HCAR2 (0.70) HCAR2KDM4EALDH1A1MEN1KMT2A
SCHEMBL4196968 0.82 HCAR2 (0.69) HCAR2TPMTSMYD3MKNK1MKNK2
Fluoride SCHEMBL21331909 0.80 HCAR2 (0.67) HCAR2KDM4EALDH1A1MEN1KMT2A
Bromide SCHEMBL21332093 0.80 HCAR2 (0.67) HCAR2KDM4EALDH1A1MEN1KMT2A
Hydrochloric Acid SCHEMBL7661020 0.80 HCAR2 (0.67) HCAR2KDM4EALDH1A1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 425 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-221867613-U Convenient clear 5-chloronicotinic acid separator 浙江荣凯科技发展股份有限公司 2024-10-22 CN claimed
CN-118724802-A Method for separating and purifying 5-chloronicotinic acid from 2-chloronicotinic acid crystallization mother liquor 浙江荣凯科技发展股份有限公司 2024-10-01 CN claimed
CN-117683754-A Nitrilase mutant and application thereof in pesticide synthesis 浙江工业大学 2024-03-12 CN claimed
CN-116987064-B Preparation method and application of pyrimidine bisnicotinamide derivative 宁夏佰斯特医药化工有限公司 2024-01-26 CN claimed
CN-117299031-A Separation and purification device and method for preparing 5-chloronicotinic acid 浙江荣凯科技发展股份有限公司 2023-12-29 CN claimed
CN-220257411-U 5-chloronicotinic acid separation and purification device 浙江荣凯科技发展股份有限公司 2023-12-29 CN claimed
CN-117126158-A Synthesis method of loniergoline 江苏汉斯通药业有限公司 2023-11-28 CN claimed
CN-116987064-A Preparation method and application of pyrimidine bisnicotinamide derivative 宁夏佰斯特医药化工有限公司 2023-11-03 CN claimed
CN-113943947-B Composite film electrode for electrochemical reduction of carbon dioxide and preparation method thereof 浙江工业大学 2022-11-15 CN claimed
CN-113943947-A Composite film electrode for electrochemical reduction of carbon dioxide and preparation method thereof 浙江工业大学 2022-01-18 CN claimed
CN-109212051-B Gas chromatography-mass spectrometry combined method for determining nine trace amounts of halogenated nicotinic acid in drinking water 丁立平 2021-11-19 CN claimed
CN-113046734-A Bivalent palladium complex solution and preparation method and application thereof 上海天承化学有限公司 2021-06-29 CN claimed
CN-109212051-A The gas chromatography-mass spectrometry of nine kinds of halogenated niacin of trace in a kind of measurement drinking water 丁立平 2019-01-15 CN claimed
WO-2006073361-A9 NOVEL PYRIDINE COMPOUNDS ASTRAZENECA AB (SE) 2007-08-02 WO claimed
US-5430049-A Treating hyperproliferative disorders GAUT ZANE N (US) 1995-07-04 US claimed
CN-121652407-A Preparation method and application of mixed valence state and Cu/Eu bimetallic MOF material 烟台大学 2026-03-13 CN disclosed
US-20250375526-A1 IRAK DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS INC (US) 2025-12-11 US disclosed
US-5364939-A Chlorinating hydroxy carboxylic acid with phosphorus pentachloride in phosphoroxy chloride LONZA LTD. (CH) 1994-11-15 US disclosed
WO-1994022868-A1 7-AZABICYCLO-[2.2.1]-HEPTANE AND -HEPTENE DERIVATIVES AS ANALGESICS AND ANTI-INFLAMMATORY AGENTS UNIVERSITY OF VIRGINIA (US) 1994-10-13 WO disclosed
US-4093622-A Pyridine esters of cyclopropane-carboxylic acid ZOECON CORPORATION (US) 1978-06-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250375526-A1 IRAK DEGRADERS AND USES THEREOF IRAK2, IRAK3, IRAK1 HCAR2 983/4885KDM4E 190/4885ALDH1A1 2776/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.