Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 16/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 10/20 | 0.50 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.50 |
| ▸ | PIK3R1 | P27986 | 4/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.48 |
| ▸ | MTOR | P42345 | 3/20 | 0.39 |
| ▸ | PRKDC | P78527 | 3/20 | 0.39 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL994202 | 0.86 | PIK3CD (0.58) | PIK3CDPIK3CAPIK3CBPIK3R1CYP3A4 | |
| SCHEMBL1195081 | 0.81 | PIK3CD (0.55) | PIK3CDPIK3CAPIK3CBPIK3R1CYP3A4 | |
| SCHEMBL1194090 | 0.81 | PIK3CD (0.51) | PIK3CDPIK3CAPIK3CBPIK3R1CYP3A4 | |
| SCHEMBL995499 | 0.78 | PIK3CD (0.55) | PIK3CDPIK3CAPIK3CBPIK3R1CYP3A4 | |
| SCHEMBL13983595 | 0.75 | PIK3CD (0.62) | PIK3CDPIK3CAPIK3CBPIK3R1CYP3A4 | |
| SCHEMBL13983591 | 0.74 | PIK3CD (0.59) | PIK3CDPIK3CAPIK3CBPIK3R1CYP3A4 | |
| SCHEMBL13983857 | 0.74 | PIK3CD (0.60) | PIK3CDPIK3CAPIK3CBPIK3R1CYP3A4 | |
| SCHEMBL13983784 | 0.74 | PIK3CD (0.76) | PIK3CDPIK3CAPIK3CBPIK3R1CYP3A4 | |
| SCHEMBL13983593 | 0.74 | PIK3CD (0.62) | PIK3CDPIK3CAPIK3CBPIK3R1CYP3A4 | |
| SCHEMBL994876 | 0.73 | PIK3CD (0.52) | PIK3CDPIK3CAPIK3CBPIK3R1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008152394-A1 | PHARMACEUTICAL COMPOUNDS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-12-18 | — | — | WO | claimed |