Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 16/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL281809 | 0.83 | SCN9A (0.55) | SCN9AMEN1KMT2ATP53ALDH1A1 | |
| SCHEMBL281621 | 0.80 | SCN9A (0.57) | SCN9AMEN1KMT2AALDH1A1RAB9A | |
| SCHEMBL281931 | 0.79 | SCN9A (0.58) | SCN9AMEN1KMT2ATP53ALDH1A1 | |
| SCHEMBL4597294 | 0.78 | SCN9A (1.00) | SCN9A | |
| SCHEMBL281749 | 0.78 | SCN9A (0.57) | SCN9AMEN1KMT2ATP53ALDH1A1 | |
| SCHEMBL281538 | 0.76 | SCN9A (0.58) | SCN9AMEN1KMT2AALDH1A1RAB9A | |
| SCHEMBL281834 | 0.76 | SCN9A (0.57) | SCN9AMEN1KMT2ATP53ALDH1A1 | |
| SCHEMBL281613 | 0.75 | SCN9A (0.55) | SCN9AMEN1KMT2ATP53ALDH1A1 | |
| SCHEMBL282033 | 0.75 | SCN9A (0.55) | SCN9AMEN1KMT2AALDH1A1RAB9A | |
| SCHEMBL283963 | 0.74 | SCN9A (0.57) | SCN9AMEN1KMT2ATP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888595-A2 | SPIRO-OXINDOLE COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006110917-A2 | SPIRO-OXINDOLE COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2006-10-19 | — | — | WO | disclosed |