Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPL | P40238 | 18/20 | 0.66 |
| ▸ | RAF1 | P04049 | 2/20 | 0.47 |
| ▸ | ARAF | P10398 | 2/20 | 0.47 |
| ▸ | BRAF | P15056 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4875198 | 0.87 | MPL (0.64) | MPLRAF1ARAFBRAF | |
| SCHEMBL4873082 | 0.83 | MPL (0.81) | MPL | |
| SCHEMBL4877629 | 0.82 | MPL (0.71) | MPL | |
| SCHEMBL4879403 | 0.81 | MPL (0.80) | MPL | |
| SCHEMBL4878023 | 0.80 | MPL (1.00) | MPL | |
| SCHEMBL4878136 | 0.79 | MPL (1.00) | MPL | |
| SCHEMBL4872307 | 0.77 | MPL (0.62) | MPL | |
| SCHEMBL4873876 | 0.76 | MPL (0.79) | MPL | |
| SCHEMBL4873040 | 0.75 | MPL (0.91) | MPL | |
| SCHEMBL4879510 | 0.73 | MPL (0.82) | MPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080076771-A1 | Thrombopoietin Receptor Agonists | REITER LAWRENCE A | 2008-03-27 | — | — | US | claimed |
| US-20080076771-A1 | Thrombopoietin Receptor Agonists | REITER LAWRENCE A | 2008-03-27 | — | — | US | disclosed |
| EP-1794156-A2 | TROMBOPOIETIN RECEPTOR AGONISTS | Pfizer Products Incorporated (US) | 2007-06-13 | — | — | EP | disclosed |
| WO-2006033005-A2 | THROMBOPOIETIN RECEPTOR AGONISTS | PFIZER PRODUCTS INC. (US) | 2006-03-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080076771-A1 | Thrombopoietin Receptor Agonists | MPL, THPO, TBXA2R | MPL 1/4885RAF1 2686/4885ARAF 2491/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.