Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 8/20 | 0.77 |
| ▸ | MAP4K4 | O95819 | 8/20 | 0.77 |
| ▸ | MARK3 | P27448 | 8/20 | 0.77 |
| ▸ | AXL | P30530 | 8/20 | 0.77 |
| ▸ | MAP4K2 | Q12851 | 8/20 | 0.77 |
| ▸ | STK3 | Q13188 | 8/20 | 0.77 |
| ▸ | SLK | Q9H2G2 | 8/20 | 0.77 |
| ▸ | MKNK2 | Q9HBH9 | 8/20 | 0.77 |
| ▸ | MINK1 | Q8N4C8 | 7/20 | 0.77 |
| ▸ | LIMK1 | P53667 | 7/20 | 0.77 |
| ▸ | MARK2 | Q7KZI7 | 7/20 | 0.77 |
| ▸ | CLK4 | Q9HAZ1 | 7/20 | 0.77 |
| ▸ | LCK | P06239 | 7/20 | 0.77 |
| ▸ | BLK | P51451 | 7/20 | 0.77 |
| ▸ | BRSK1 | Q8TDC3 | 6/20 | 0.77 |
| ▸ | CDK1 | P06493 | 6/20 | 0.77 |
| ▸ | MET | P08581 | 6/20 | 0.77 |
| ▸ | MAP4K5 | Q9Y4K4 | 6/20 | 0.77 |
| ▸ | SRPK1 | Q96SB4 | 6/20 | 0.77 |
| ▸ | CSNK1G2 | P78368 | 6/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4760435 | 0.88 | PLK4 (0.62) | PLK4MAP4K4MARK3AXLMAP4K2 | |
| SCHEMBL5478260 | 0.87 | PLK4 (1.00) | PLK4MAP4K4MARK3AXLMAP4K2 | |
| SCHEMBL4721372 | 0.81 | PLK4 (0.89) | PLK4MAP4K4MARK3AXLMAP4K2 | |
| SCHEMBL5474622 | 0.77 | PLK4 (0.80) | PLK4MAP4K4MARK3AXLMAP4K2 | |
| SCHEMBL4761640 | 0.76 | PLK4 (0.81) | PLK4MAP4K4MARK3AXLMAP4K2 | |
| SCHEMBL5472353 | 0.76 | KDR (1.00) | PLK4MAP4K4MARK3AXLMAP4K2 | |
| SCHEMBL5474949 | 0.76 | MAP4K4 (0.78) | PLK4MAP4K4MARK3AXLMAP4K2 | |
| SCHEMBL4722423 | 0.76 | PLK4 (1.00) | PLK4MAP4K4MARK3AXLMAP4K2 | |
| SCHEMBL4719761 | 0.76 | PLK4 (1.00) | PLK4MAP4K4MARK3AXLMAP4K2 | |
| SCHEMBL4721626 | 0.76 | STK3 (0.78) | PLK4MAP4K4MARK3AXLMAP4K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968979-A2 | 9-MEMBERED HETEROBICYCLIC COMPOUNDS AS INHIBITORS OF PROTEIN KINASES | ABBOTT LABORATORIES (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007067781-A2 | 9-MEMBERED HETEROBICYCLIC COMPOUNDS AS INHIBITORS OF PROTEIN KINASES | ABBOTT LABORATORIES (US) | 2007-06-14 | — | — | WO | disclosed |