Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 7/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.45 |
| ▸ | GSTO1 | P78417 | 2/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.42 |
| ▸ | TTPA | P49638 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9632542 | 0.90 | PSEN1 (0.45) | PSEN1MEN1KMT2APDE4APDE3A | |
| SCHEMBL9075342 | 0.87 | PSEN1 (0.46) | PSEN1MEN1KMT2APDE4APDE3A | |
| SCHEMBL10346932 | 0.87 | MEN1 (0.48) | PSEN1MEN1KMT2APDE4APDE3A | |
| SCHEMBL15854991 | 0.85 | PSEN1 (0.43) | PSEN1MEN1KMT2APDE4APDE3A | |
| SCHEMBL9076030 | 0.85 | PSEN1 (0.44) | PSEN1MEN1KMT2APDE4APDE3A | |
| SCHEMBL5165669 | 0.84 | PSEN1 (0.43) | PSEN1MEN1KMT2APDE4APDE3A | |
| SCHEMBL9075833 | 0.84 | PSEN1 (0.48) | PSEN1MEN1KMT2APDE4APDE3A | |
| SCHEMBL9074206 | 0.83 | PSEN1 (0.58) | PSEN1MEN1KMT2APDE4APDE3A | |
| SCHEMBL9280072 | 0.83 | PSEN1 (0.52) | PSEN1MEN1KMT2APDE4APDE3A | |
| SCHEMBL9073758 | 0.81 | PSEN1 (0.43) | PSEN1MEN1KMT2APDE4APDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7384558-B2 | Compositions capable of inhibiting reactive oxygen and carbonyl species | BAXTER INTERNATIONAL INC. (US) | 2008-06-10 | — | — | US | disclosed |
| EP-1771168-A1 | COMPOSITIONS CAPABLE OF INHIBITING REACTIVE OXYGEN AND CARBONYL SPECIES | BAXTER INTERNATIONAL INC. (US) | 2007-04-11 | — | — | EP | disclosed |
| WO-2006019855-A1 | COMPOSITIONS CAPABLE OF INHIBITING REACTIVE OXYGEN AND CARBONYL SPECIES | BAXTER INTERNATIONAL INC. (US) | 2006-02-23 | — | — | WO | disclosed |
| US-20060016752-A1 | Dialysis solution containing single compound with an antioxidant group, e.g., vitamin E, cinnamic acid derivatives, pyridoxamine, flavonoids, lipoic acid, linked to a carbonyl-trapping group, e.g., aminooxy or 1,2-aminothiol group via, e.g., piperazine, poly(ethylene glycol), or lysine; antiinflammatory | BAXTER INTERNATIONAL INC. | 2006-01-26 | — | — | US | disclosed |
| US-5508450-A | INHIBITORY EFFECT ON MAILLARD REACTION AND ANTIOXIDIZING EFFECT; TREATS OR PREVENTS DIABETIC COMPLICATIONS | ONO PHARMACEUTICAL CO., LTD. (JP) | 1996-04-16 | — | — | US | disclosed |
| EP-0387771-B1 | Benzopyran derivatives | ONO PHARMACEUTICAL CO (JP) | 1995-06-07 | — | — | EP | disclosed |
| US-5384414-A | Compounds with guanidine groups | ONO PHARMACEUTICAL CO., LTD. (JP) | 1995-01-24 | — | — | US | disclosed |
| US-5266709-A | Treatment of diabetic complications | ONO PHARMACEUTICAL CO., LTD. (JP) | 1993-11-30 | — | — | US | disclosed |
| US-5169957-A | Antidiabetic agents | ONO PHARMACEUTICAL CO., LTD. (JP) | 1992-12-08 | — | — | US | disclosed |
| US-5055598-A | Prevention and treatment of diabetic complications, diseases of aging and formation of peroxidized fat; antioxidants | ONO PHARMACEUTICAL CO., LTD. (JP) | 1991-10-08 | — | — | US | disclosed |
| EP-0387771-A2 | Benzopyran derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 1990-09-19 | — | — | EP | disclosed |