Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 3/20 | 0.54 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | EP300 | Q09472 | 3/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.33 |
| ▸ | CDK2 | P24941 | 3/20 | 0.33 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.33 |
| ▸ | AURKA | O14965 | 2/20 | 0.33 |
| ▸ | INSR | P06213 | 2/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.33 |
| ▸ | PRKCB | P05771 | 1/20 | 0.33 |
| ▸ | PAK4 | O96013 | 1/20 | 0.33 |
| ▸ | HMOX1 | P09601 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14496599 | 0.93 | IGF1R (0.55) | IGF1RMETEP300CREBBPKIT | |
| SCHEMBL1897920 | 0.92 | IGF1R (0.53) | IGF1RMETEP300CREBBPKIT | |
| SCHEMBL12663058 | 0.90 | IGF1R (0.51) | IGF1RMETEP300CREBBPKIT | |
| Hydrochloric Acid SCHEMBL1887428 | 0.89 | IGF1R (0.50) | IGF1RMETEP300CREBBPKIT | |
| SCHEMBL1894241 | 0.87 | IGF1R (0.49) | IGF1RMETKITFLT3AURKA | |
| SCHEMBL2677477 | 0.85 | IGF1R (0.54) | IGF1RMETEP300CREBBPKIT | |
| SCHEMBL2677466 | 0.84 | IGF1R (0.54) | IGF1RMETEP300CREBBPKIT | |
| SCHEMBL1887232 | 0.80 | IGF1R (0.55) | IGF1RMETKITFLT3CCNA2 | |
| SCHEMBL1886685 | 0.80 | IGF1R (0.69) | IGF1RMETEP300CREBBPKIT | |
| SCHEMBL1891706 | 0.80 | IGF1R (0.51) | IGF1RMETKITFLT3AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968976-A1 | SUBSTITUTED PYRAZOLO [4,3-C] PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007068619-A1 | SUBSTITUTED PYRAZOLO [4,3-C] PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2007-06-21 | — | — | WO | disclosed |