Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 2/20 | 0.49 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.49 |
| ▸ | LYN | P07948 | 3/20 | 0.42 |
| ▸ | HCK | P08631 | 2/20 | 0.42 |
| ▸ | INSR | P06213 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 11/20 | 0.42 |
| ▸ | CSF1R | P07333 | 3/20 | 0.42 |
| ▸ | RAF1 | P04049 | 3/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | NR2C2 | P49116 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | TEK | Q02763 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | ARAF | P10398 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3387035 | 0.85 | MAP3K7 (0.59) | MAP3K7MAP4K2LYNHCKINSR | |
| SCHEMBL3387007 | 0.78 | MAP3K7 (0.51) | MAP3K7MAP4K2LYNHCKINSR | |
| SCHEMBL3387657 | 0.78 | MAP3K7 (0.51) | MAP3K7MAP4K2LYNHCKINSR | |
| SCHEMBL3387002 | 0.78 | LYN (0.55) | MAP3K7MAP4K2LYNHCKINSR | |
| SCHEMBL3390724 | 0.78 | CSF1R (0.60) | MAP3K7MAP4K2LYNBRAFCSF1R | |
| SCHEMBL3384701 | 0.73 | BRAF (0.70) | MAP3K7MAP4K2BRAFCSF1RRAF1 | |
| SCHEMBL3388334 | 0.72 | CSF1R (0.60) | MAP3K7MAP4K2LYNHCKINSR | |
| SCHEMBL3391195 | 0.72 | BRAF (0.49) | LCKKDRBRAFCSF1RRAF1 | |
| SCHEMBL3386984 | 0.71 | CSF1R (0.58) | LCKKDRBRAFCSF1RRAF1 | |
| SCHEMBL14572597 | 0.70 | BRAF (0.55) | MAP3K7MAP4K2KDRBRAFRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1891066-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM, LLC (BM) | 2008-02-27 | — | — | EP | claimed |
| WO-2006124462-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM, LLC (BM) | 2006-11-23 | — | — | WO | claimed |