Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 10/20 | 0.64 |
| ▸ | MAP3K5 | Q99683 | 3/20 | 0.58 |
| ▸ | MAP3K6 | O95382 | 2/20 | 0.58 |
| ▸ | LIMK2 | P53671 | 3/20 | 0.54 |
| ▸ | STK3 | Q13188 | 2/20 | 0.52 |
| ▸ | CDC7 | O00311 | 1/20 | 0.52 |
| ▸ | PLK4 | O00444 | 1/20 | 0.52 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.52 |
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.52 |
| ▸ | PAK4 | O96013 | 1/20 | 0.52 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.52 |
| ▸ | PRKCG | P05129 | 1/20 | 0.52 |
| ▸ | INSR | P06213 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
| ▸ | FYN | P06241 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4869496 | 0.85 | LIMK2 (0.72) | AKT1MAP3K5MAP3K6LIMK2 | |
| SCHEMBL20640921 | 0.83 | AKT1 (0.85) | AKT1MAP3K5MAP3K6STK3CDC7 | |
| SCHEMBL18265826 | 0.82 | LRRK2 (0.68) | AKT1MAP3K5MAP3K6STK3LRRK2 | |
| SCHEMBL9966951 | 0.80 | MAP3K5 (0.74) | AKT1MAP3K5MAP3K6LIMK2STK3 | |
| SCHEMBL3536069 | 0.78 | AKT1 (0.69) | AKT1MAP3K5MAP3K6STK3CDC7 | |
| SCHEMBL2253909 | 0.77 | AKT1 (0.68) | AKT1MAP3K5MAP3K6STK3LRRK2 | |
| SCHEMBL20641460 | 0.77 | MAP3K5 (0.59) | AKT1MAP3K5MAP3K6STK3LRRK2 | |
| SCHEMBL30880363 | 0.76 | BTK (0.64) | LCK | |
| SCHEMBL29204261 | 0.76 | BTK (0.64) | LCK | |
| SCHEMBL24391567 | 0.75 | AKT1 (0.58) | AKT1MAP3K5MAP3K6STK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7423043-B2 | 4-Piperidin-1-yl-7H-pyrrolo[2,3-d]pyrimidine compounds | LEXICON PHARMACEUTICALS, INC. (US) | 2008-09-09 | — | — | US | disclosed |
| US-20060189638-A1 | kinase inhibitor; proliferative diseases such as cancer, cancer metastasis, inflammation, arthritis, and diseases characterized by abnormal or inappropriate angiogenesis | OXFORD FINANCE LLC, AS COLLATERAL AGENT | 2006-08-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060189638-A1 | kinase inhibitor; proliferative diseases such as cancer, cancer metastasis, inflammation, arthritis, and diseases characterized by abnormal or inappropriate angiogenesis | CDK4, CDK2, MKI67 | AKT1 237/4885MAP3K5 21/4885MAP3K6 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.