Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 2/20 | 0.47 |
| ▸ | CLK3 | P49761 | 2/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.47 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.47 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.47 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.47 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.47 |
| ▸ | MYLK2 | Q9H1R3 | 1/20 | 0.47 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.47 |
| ▸ | DYRK3 | O43781 | 5/20 | 0.44 |
| ▸ | CDK1 | P06493 | 4/20 | 0.42 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4867200 | 0.90 | PIK3CD (0.48) | CLK1CLK3DYRK1ADYRK2CLK4 | |
| SCHEMBL4867386 | 0.86 | PIK3CD (0.47) | CLK1CLK3DYRK1ADYRK2CLK4 | |
| SCHEMBL4876375 | 0.86 | PIK3CD (0.50) | CLK1CLK3DYRK1ADYRK2CLK4 | |
| SCHEMBL5224369 | 0.86 | PIK3CD (0.45) | CLK1CLK3DYRK1ADYRK2CLK4 | |
| SCHEMBL4872082 | 0.85 | MAPT (0.46) | CLK1CLK3DYRK1ADYRK2CLK4 | |
| SCHEMBL4871649 | 0.85 | PIK3CD (0.45) | CLK1CLK3DYRK1ADYRK2CLK4 | |
| SCHEMBL4876285 | 0.85 | CDK1 (0.54) | CLK1CLK3DYRK1ADYRK2CLK4 | |
| SCHEMBL4866360 | 0.83 | PIK3CD (0.46) | CLK1CLK3DYRK1ADYRK2CLK4 | |
| SCHEMBL4871989 | 0.83 | AURKA (0.50) | CLK1CLK3DYRK1ADYRK2CLK4 | |
| SCHEMBL4871717 | 0.83 | PIK3CD (0.47) | CLK1CLK3DYRK1ADYRK2CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7326786-B2 | Thiazolinone unsubstituted quinolines | HOFFMANN-LA ROCHE INC. (US) | 2008-02-05 | — | — | US | disclosed |
| EP-1765817-A1 | THIAZOLINONE UNSUBSTITUTED QUINOLINES | F.HOFFMANN-LA ROCHE AG (CH) | 2007-03-28 | — | — | EP | disclosed |
| WO-2006002829-A1 | THIAZOLINONE UNSUBSTITUTED QUINOLINES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-01-12 | — | — | WO | disclosed |
| US-20060004045-A1 | Thiazolinone unsubstituted quinolines | CHEN LI | 2006-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060004045-A1 | Thiazolinone unsubstituted quinolines | CDK1, CDK17, CDK14 | CLK1 792/4885CLK3 930/4885DYRK1A 408/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.