Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 17/20 | 0.55 |
| ▸ | CDK4 | P11802 | 4/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.48 |
| ▸ | CDK1 | P06493 | 2/20 | 0.48 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.48 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.48 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.48 |
| ▸ | CCND1 | P24385 | 1/20 | 0.48 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.48 |
| ▸ | CCND3 | P30281 | 1/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.48 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.48 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.48 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.48 |
| ▸ | GSK3A | P49840 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | CDK7 | P50613 | 1/20 | 0.48 |
| ▸ | CDK9 | P50750 | 1/20 | 0.48 |
| ▸ | CCNH | P51946 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4872406 | 1.00 | CDK2 (0.55) | CDK2CDK4KCNH2CDK1CCNT1 | |
| SCHEMBL4869998 | 0.89 | CDK2 (0.50) | CDK2CDK4KCNH2CDK1CCNT1 | |
| SCHEMBL4870005 | 0.89 | CDK2 (0.50) | CDK2CDK4KCNH2CDK1CCNT1 | |
| SCHEMBL4864767 | 0.88 | CDK2 (0.53) | CDK2CDK4KCNH2CDK1CCNT1 | |
| SCHEMBL4864773 | 0.88 | CDK2 (0.53) | CDK2CDK4KCNH2CDK1CCNT1 | |
| SCHEMBL4888853 | 0.88 | CDK2 (0.53) | CDK2CDK4KCNH2CDK1CCNT1 | |
| SCHEMBL4888859 | 0.88 | CDK2 (0.53) | CDK2CDK4KCNH2CDK1CCNT1 | |
| SCHEMBL4863588 | 0.84 | CDK2 (0.56) | CDK2CDK4KCNH2CDK1CCNT1 | |
| SCHEMBL5098885 | 0.79 | CDK2 (0.78) | CDK2CDK4KCNH2CDK1CCNT1 | |
| SCHEMBL5109492 | 0.79 | CDK2 (0.72) | CDK2CDK4KCNH2CDK1CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7427626-B2 | 2-Anilino-4-(imidazol-5-yl)-pyrimidine derivatives and their use as cdk (cdk2) inhibitors | ASTRAZENECA AB (SE) | 2008-09-23 | — | — | US | disclosed |