Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 3/20 | 0.61 |
| ▸ | MET | P08581 | 3/20 | 0.40 |
| ▸ | EP300 | Q09472 | 5/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 5/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | HMOX1 | P09601 | 2/20 | 0.35 |
| ▸ | F12 | P00748 | 3/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1888166 | 0.90 | IGF1R (0.60) | IGF1RMETEP300CREBBPCCNA2 | |
| SCHEMBL1893031 | 0.85 | IGF1R (0.72) | IGF1RMETEP300CREBBPCCNA2 | |
| SCHEMBL1889404 | 0.85 | IGF1R (0.60) | IGF1RMETEP300CREBBPCCNA2 | |
| SCHEMBL1884807 | 0.84 | IGF1R (0.56) | IGF1RMETAURKAF12 | |
| SCHEMBL1896236 | 0.83 | IGF1R (0.55) | IGF1RMETCCNA2CDK2CCNA1 | |
| SCHEMBL1894216 | 0.83 | IGF1R (0.57) | IGF1RMETEP300CREBBPCCNA2 | |
| SCHEMBL1885146 | 0.83 | IGF1R (0.52) | IGF1RMETDPP4DPP8 | |
| SCHEMBL1889115 | 0.83 | IGF1R (0.52) | IGF1RMETDPP4DPP8 | |
| SCHEMBL1885148 | 0.83 | IGF1R (0.52) | IGF1RMETDPP4DPP8 | |
| SCHEMBL1889723 | 0.82 | IGF1R (0.52) | IGF1RMETCCNA2CDK2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968976-A1 | SUBSTITUTED PYRAZOLO [4,3-C] PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007068619-A1 | SUBSTITUTED PYRAZOLO [4,3-C] PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2007-06-21 | — | — | WO | disclosed |