Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | VCP | P55072 | 2/20 | 0.48 |
| ▸ | ASIC3 | Q9UHC3 | 2/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.45 |
| ▸ | PLAU | P00749 | 1/20 | 0.45 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6710661 | 0.86 | HDAC6 (0.55) | HDAC6VCPASIC3F2KCNQ2 | |
| SCHEMBL167256 | 0.86 | HDAC6 (0.52) | HDAC6VCPASIC3F2KCNQ2 | |
| SCHEMBL976938 | 0.86 | F2 (0.59) | HDAC6VCPF2PLAUMAPT | |
| SCHEMBL15223715 | 0.85 | HDAC6 (0.55) | HDAC6ASIC3F2CA12CA1 | |
| SCHEMBL2721413 | 0.83 | HPN (0.50) | HDAC6VCPF2KCNQ2CREBBP | |
| SCHEMBL693207 | 0.83 | CYP19A1 (0.52) | HDAC6VCPF2KCNQ2PLAU | |
| SCHEMBL4865944 | 0.82 | CYP19A1 (0.55) | HDAC6VCPF2PLAUMAPT | |
| SCHEMBL164054 | 0.82 | HDAC6 (0.47) | HDAC6VCPKCNQ2CREBBPRAB9A | |
| SCHEMBL18792826 | 0.81 | HDAC6 (0.58) | HDAC6ASIC3F2CA12CA1 | |
| SCHEMBL12392442 | 0.81 | HDAC6 (0.52) | HDAC6ASIC3F2CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7375118-B2 | Phenyl-indole compounds for modulating IgE and Inhibiting cellular proliferation | AVANIR PHARMACEUTICALS (US) | 2008-05-20 | — | — | US | disclosed |
| CN-1694868-A | Phenyl-indole compounds for modulating IgE and inhibiting cell proliferation | AVANIR PHARMACEUTICALS (US) | 2005-11-09 | — | — | CN | disclosed |
| US-20040180946-A1 | Phenyl-indole compounds for modulating IgE and inhibiting cellular proliferation | AVANIR PHARMACEUTICALS | 2004-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040180946-A1 | Phenyl-indole compounds for modulating IgE and inhibiting cellular proliferation | IDO1, IDO2, CMA1 | HDAC6 1234/4885VCP 4718/4885ASIC3 4680/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.