Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 15/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.37 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.37 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.37 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.35 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.35 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4778445 | 0.84 | HDAC8 (0.65) | HDAC8HDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL4770102 | 0.82 | HDAC8 (0.67) | HDAC8HDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL4775526 | 0.79 | HDAC8 (0.73) | HDAC8HDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL4778060 | 0.76 | HDAC8 (0.69) | HDAC8HDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL4779469 | 0.75 | HDAC8 (0.76) | HDAC8HDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL4779462 | 0.75 | HDAC8 (0.76) | HDAC8HDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL4772336 | 0.74 | HDAC8 (0.71) | HDAC8HDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL4772737 | 0.74 | HDAC8 (0.60) | HDAC8HDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL4772725 | 0.74 | HDAC8 (0.78) | HDAC8HDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL4909818 | 0.73 | HDAC8 (0.69) | HDAC8HDAC1HDAC3HDAC2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1996550-A2 | CARBOXYAMINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF HDAC DEPENDENT DISEASES | Novartis AG (CH) | 2008-12-03 | — | — | EP | claimed |
| WO-2007038459-A2 | CARBOXYAMINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF HDAC DEPENDENT DISEASES | NOVARTIS AG (CH) | 2007-04-05 | — | — | WO | claimed |