Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 2/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 5/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4812977 | 0.83 | PTGS1 (0.34) | PTGS1PTGS2TGFBR1FLT3IRAK4 | |
| SCHEMBL4808161 | 0.81 | PTGS1 (0.39) | PTGS1PTGS2FLT3IRAK4CYP1A2 | |
| SCHEMBL14194714 | 0.80 | PDE10A (0.42) | PTGS1PTGS2FLT3MAPTKMT2A | |
| SCHEMBL14194753 | 0.77 | MAPK10 (0.35) | PTGS2TGFBR1MAPTPPP1CAKMT2A | |
| SCHEMBL4808476 | 0.77 | PTGS1 (0.38) | PTGS1PTGS2FLT3IRAK4CYP1A2 | |
| SCHEMBL4809497 | 0.76 | KMT2A (0.43) | PTGS1PTGS2FLT3IRAK4CYP1A2 | |
| SCHEMBL4806864 | 0.76 | PDE10A (0.43) | PTGS1PTGS2FLT3CYP1A2MAPT | |
| SCHEMBL4869273 | 0.76 | PDE10A (0.47) | MAPTKMT2APDE10A | |
| SCHEMBL4807541 | 0.76 | MAPT (0.43) | PTGS1PTGS2IRAK4CYP1A2MAPT | |
| SCHEMBL4878495 | 0.75 | PTGS1 (0.36) | PTGS1PTGS2TGFBR1FLT3IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080090834-A1 | SELECTIVE AZOLE PDE10A INHIBITOR COMPOUNDS | PFIZER INC | 2008-04-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080090834-A1 | SELECTIVE AZOLE PDE10A INHIBITOR COMPOUNDS | PDE5A, PDE3B, PDE12 | PTGS1 527/4885PTGS2 854/4885TGFBR1 1344/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.