Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4878462 | 0.90 | KCNK3 (0.53) | NPC1RAB9ALMNAKDM4EALDH1A1 | |
| SCHEMBL2208057 | 0.75 | KCNA5 (0.72) | NPC1RAB9AKCNA5MAPTALDH1A1 | |
| SCHEMBL4626781 | 0.73 | HTT (0.68) | NPC1RAB9AKCNA5MAPTLMNA | |
| SCHEMBL2210182 | 0.72 | KCNA5 (0.65) | NPC1RAB9AKCNA5MAPTLMNA | |
| SCHEMBL2210786 | 0.71 | KCNA5 (0.67) | NPC1RAB9AKCNA5MAPTLMNA | |
| SCHEMBL2206886 | 0.70 | KCNA5 (0.60) | NPC1RAB9AKCNA5MAPTLMNA | |
| SCHEMBL2205271 | 0.69 | KCNA5 (0.59) | KCNA5 | |
| SCHEMBL2210421 | 0.69 | KCNA5 (0.60) | NPC1RAB9AKCNA5MAPTHTT | |
| SCHEMBL6356707 | 0.69 | NPC1 (1.00) | NPC1RAB9APTGS2MAPTLMNA | |
| SCHEMBL12434478 | 0.67 | KCNA5 (0.73) | NPC1RAB9AKCNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1942888-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-07-16 | — | — | EP | disclosed |
| WO-2007056078-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-18 | — | — | WO | disclosed |