Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 12/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.44 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 12/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 9/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 6/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.40 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1221050 | 0.81 | CYP3A4 (0.50) | CYP3A4KMT2AMEN1OPRD1NPSR1 | |
| SCHEMBL9358880 | 0.76 | NPSR1 (0.56) | CYP3A4KMT2AMEN1OPRM1OPRD1 | |
| SCHEMBL27827700 | 0.76 | CYP3A4 (0.43) | CYP3A4KMT2AMEN1OPRM1OPRD1 | |
| SCHEMBL71724 | 0.71 | NPSR1 (0.57) | CYP3A4KMT2AOPRM1OPRD1OPRK1 | |
| SCHEMBL14677513 | 0.71 | CYP3A4 (0.49) | CYP3A4KMT2AMEN1OPRM1OPRD1 | |
| SCHEMBL10047375 | 0.70 | NPSR1 (0.61) | CYP3A4KMT2AMEN1OPRM1OPRD1 | |
| SCHEMBL4782320 | 0.70 | CYP3A4 (0.51) | CYP3A4KMT2AMEN1OPRM1OPRD1 | |
| SCHEMBL10569014 | 0.70 | CYP3A4 (0.54) | CYP3A4KMT2AMEN1OPRM1OPRD1 | |
| Hydrochloric Acid SCHEMBL2951072 | 0.70 | NPSR1 (0.56) | CYP3A4KMT2AOPRM1OPRD1OPRK1 | |
| SCHEMBL2196605 | 0.70 | OPRL1 (0.44) | CYP3A4KMT2AMEN1OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080085884-A1 | Melanin Concentrating Hormone Receptor-1 Antagonist Pyridinones | PFIZER INC | 2008-04-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080085884-A1 | Melanin Concentrating Hormone Receptor-1 Antagonist Pyridinones | MCHR1, MCHR2, MC1R | CYP3A4 390/4885KMT2A 2091/4885MEN1 434/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.