Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.50 |
| ▸ | CES1 | P23141 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | GSK3B | P49841 | 2/20 | 0.45 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1507309 | 0.82 | HIF1A (0.52) | SMN1; SMN2HIF1ACES1ALDH1A1MAPK1 | |
| SCHEMBL1507308 | 0.82 | HIF1A (0.52) | SMN1; SMN2HIF1ACES1ALDH1A1MAPK1 | |
| SCHEMBL10616915 | 0.82 | HIF1A (0.52) | SMN1; SMN2HIF1ACES1ALDH1A1MAPK1 | |
| SCHEMBL27863809 | 0.81 | HIF1A (0.50) | SMN1; SMN2HIF1ACES1ALDH1A1MAPK1 | |
| SCHEMBL2850327 | 0.81 | SMN1; SMN2 (0.50) | SMN1; SMN2HIF1ACES1ALDH1A1MAPK1 | |
| SCHEMBL27846723 | 0.81 | HIF1A (0.50) | SMN1; SMN2HIF1ACES1ALDH1A1MAPK1 | |
| SCHEMBL27846724 | 0.81 | HIF1A (0.50) | SMN1; SMN2HIF1ACES1ALDH1A1MAPK1 | |
| SCHEMBL2161616 | 0.81 | HIF1A (0.50) | SMN1; SMN2HIF1ACES1ALDH1A1MAPK1 | |
| SCHEMBL3132247 | 0.80 | CES1 (0.48) | SMN1; SMN2HIF1ACES1ALDH1A1MAPK1 | |
| SCHEMBL2225057 | 0.79 | SMN1; SMN2 (0.75) | SMN1; SMN2HIF1ACES1MAPK1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7459472-B2 | Aryl and heteroaryl compounds, compositions, and methods of use | TRANSTECH PHARMA, INC. (US) | 2008-12-02 | — | — | US | disclosed |
| US-20050059713-A1 | Aryl and heteroaryl compounds, compositions, and methods of use | VTVX HOLDINGS I LLC | 2005-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050059713-A1 | Aryl and heteroaryl compounds, compositions, and methods of use | CYP2F1, CYP3A43, PNPO | SMN1; SMN2 2981/4885HIF1A 1228/4885CES1 430/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.