Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 9/20 | 0.61 |
| ▸ | CSF1R | P07333 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | BCR | P11274 | 5/20 | 0.59 |
| ▸ | BRAF | P15056 | 4/20 | 0.59 |
| ▸ | HCK | P08631 | 4/20 | 0.59 |
| ▸ | RAF1 | P04049 | 3/20 | 0.59 |
| ▸ | LCK | P06239 | 3/20 | 0.59 |
| ▸ | LYN | P07948 | 3/20 | 0.59 |
| ▸ | SRC | P12931 | 3/20 | 0.59 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.59 |
| ▸ | LDLR | P01130 | 2/20 | 0.59 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.59 |
| ▸ | KIT | P10721 | 2/20 | 0.59 |
| ▸ | PCSK9 | Q8NBP7 | 2/20 | 0.59 |
| ▸ | EPHB2 | P29323 | 2/20 | 0.59 |
| ▸ | FYN | P06241 | 2/20 | 0.59 |
| ▸ | YES1 | P07947 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4630979 | 0.83 | BRAF (0.68) | ABL1CSF1RPOLBBRAFRAF1 | |
| SCHEMBL5222415 | 0.83 | ABL1 (0.84) | ABL1CSF1RBCRBRAFHCK | |
| SCHEMBL15381989 | 0.79 | CSF1R (0.71) | ABL1CSF1RKDM4EPOLBRECQL | |
| SCHEMBL22025121 | 0.78 | ABL1 (0.63) | ABL1CSF1RKDM4EPOLBRECQL | |
| SCHEMBL6451143 | 0.78 | KDM4E (0.64) | ABL1CSF1RKDM4EPOLBRECQL | |
| SCHEMBL27708222 | 0.78 | PIKFYVE (0.55) | ABL1CSF1RBCRBRAFPDGFRB | |
| SCHEMBL2465750 | 0.78 | LCK (0.70) | CSF1RKDM4EPOLBRECQLHCK | |
| SCHEMBL15556278 | 0.77 | EPHB2 (0.82) | ABL1CSF1RKDM4EPOLBRECQL | |
| SCHEMBL21612152 | 0.76 | CSF1R (0.71) | ABL1CSF1RKDM4EPOLBRECQL | |
| SCHEMBL4252904 | 0.76 | CSF1R (0.68) | ABL1CSF1RKDM4EPOLBRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080146570-A1 | Chemical Compounds | ASTRAZENECA AB (SE) | 2008-06-19 | — | — | US | claimed |
| US-20080146570-A1 | Chemical Compounds | ASTRAZENECA AB (SE) | 2008-06-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080146570-A1 | Chemical Compounds | BRAF, RAF1, NRAS | ABL1 20/4885CSF1R 1706/4885KDM4E 2971/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.