Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 13/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 13/20 | 0.48 |
| ▸ | DRD2 | P14416 | 10/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | BMPR1B | O00238 | 4/20 | 0.40 |
| ▸ | BMPR1A | P36894 | 4/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.40 |
| ▸ | ACVRL1 | P37023 | 4/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 4/20 | 0.40 |
| ▸ | TYMS | P04818 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3567551 | 1.00 | DRD3 (0.48) | DRD3KCNH2DRD2CYP1A2BMPR1B | |
| Hydrochloric Acid SCHEMBL3569364 | 0.99 | DRD3 (0.47) | DRD3KCNH2DRD2CYP1A2BMPR1B | |
| SCHEMBL3565544 | 0.91 | DRD3 (0.48) | DRD3KCNH2DRD2CYP1A2BMPR1B | |
| SCHEMBL3560605 | 0.91 | DRD3 (0.59) | DRD3KCNH2DRD2CYP1A2BMPR1B | |
| Hydrochloric Acid SCHEMBL3557187 | 0.91 | DRD3 (0.48) | DRD3KCNH2DRD2CYP1A2BMPR1B | |
| Hydrochloric Acid SCHEMBL3565670 | 0.90 | DRD3 (0.58) | DRD3KCNH2DRD2CYP1A2BMPR1B | |
| SCHEMBL4664177 | 0.87 | DRD3 (0.47) | DRD3KCNH2DRD2CYP1A2BMPR1B | |
| SCHEMBL3565408 | 0.87 | DRD3 (0.47) | DRD3KCNH2DRD2CYP1A2BMPR1B | |
| SCHEMBL3563499 | 0.87 | DRD3 (0.48) | DRD3KCNH2DRD2CYP1A2BMPR1B | |
| SCHEMBL2744774 | 0.86 | DRD3 (0.47) | DRD3KCNH2DRD2CYP1A2BMPR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007750-A1 | AZABICYCLO [3. 1. 0] HEXYL DERIVATIVES AS MODULATORS OF DOPAMINE D3 RECEPTORS | GLAXO GROUP LIMITED (GB) | 2008-12-31 | — | — | EP | disclosed |
| WO-2007113232-A1 | AZABICYCLO [3. 1. 0] HEXYL DERIVATIVES AS MODULATORS OF DOPAMINE D3 RECEPTORS | GLAXO GROUP LIMITED (GB) | 2007-10-11 | — | — | WO | disclosed |