Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2J2 | P51589 | 13/20 | 0.75 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.68 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.68 |
| ▸ | HRH1 | P35367 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | DRD3 | P35462 | 2/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.55 |
| ▸ | CNR1 | P21554 | 1/20 | 0.55 |
| ▸ | APEX1 | P27695 | 1/20 | 0.55 |
| ▸ | PDE4A | P27815 | 1/20 | 0.55 |
| ▸ | HTR2A | P28223 | 1/20 | 0.55 |
| ▸ | HTR2B | P41595 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.55 |
| ▸ | DRD2 | P14416 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2235075 | 0.99 | CYP2J2 (0.74) | CYP2J2CYP3A4CYP2C9CYP2B6HRH1 | |
| SCHEMBL2265221 | 0.90 | CYP2J2 (0.78) | CYP2J2CYP3A4CYP2C9CYP2B6HRH1 | |
| Hydrochloric Acid SCHEMBL2985989 | 0.90 | CYP2J2 (0.76) | CYP2J2CYP3A4CYP2C9CYP2B6HRH1 | |
| SCHEMBL1395734 | 0.88 | CYP2J2 (0.84) | CYP2J2CYP3A4CYP2C9CYP2B6HRH1 | |
| SCHEMBL13525525 | 0.87 | CYP2J2 (0.82) | CYP2J2CYP3A4CYP2C9CYP2B6HRH1 | |
| SCHEMBL18765452 | 0.87 | CYP2J2 (0.82) | CYP2J2CYP3A4CYP2C9CYP2B6HRH1 | |
| Hydrochloric Acid SCHEMBL3681404 | 0.87 | CYP2J2 (0.82) | CYP2J2CYP3A4CYP2C9CYP2B6HRH1 | |
| SCHEMBL11376047 | 0.87 | CYP2J2 (0.58) | CYP2J2CYP3A4CYP2C9CYP2B6HRH1 | |
| SCHEMBL18765451 | 0.86 | CYP2J2 (0.81) | CYP2J2CYP3A4CYP2C9CYP2B6HRH1 | |
| SCHEMBL11826925 | 0.86 | CYP2J2 (1.00) | CYP2J2CYP3A4CYP2C9CYP2B6HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 73 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030045722-A1 | Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudomorphs thereof | HENTON DANIEL R (US) | 2003-03-06 | — | — | US | claimed |
| US-20020193600-A1 | Process for preparing anyhdrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudomorphs thereof | HENTON DANIEL R (US) | 2002-12-19 | — | — | US | claimed |
| US-20020193603-A1 | Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudomorphs thereof | AVENTISUB II INC. | 2002-12-19 | — | — | US | claimed |
| US-20020193601-A1 | Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudomorphs thereof | AVENTISUB II INC. | 2002-12-19 | — | — | US | claimed |
| EP-1178041-A1 | Process for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives | Aventis Pharmaceuticals Inc. (US) | 2002-02-06 | — | — | EP | claimed |
| US-20010025106-A1 | Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudomorphs thereof | HENTON DANIEL R (US) | 2001-09-27 | — | — | US | claimed |
| US-20010014741-A1 | Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudomorphs thereof | HENTON DANIEL R (US) | 2001-08-16 | — | — | US | claimed |
| US-20010012896-A1 | Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudomorphs thereof | HENTON DANIEL R (US) | 2001-08-09 | — | — | US | claimed |
| EP-0766668-A1 | PROCESSES FOR PREPARING ANHYDROUS AND HYDRATE FORMS OF ANTIHISTAMINIC PIPERIDINE DERIVATIVES, POLYMORPHS AND PSEUDORMOPHS THEREOF | HOECHST MARION ROUSSEL, INC. (US) | 1997-04-09 | — | — | EP | claimed |
| WO-1995031437-A1 | PROCESSES FOR PREPARING ANHYDROUS AND HYDRATE FORMS OF ANTIHISTAMINIC PIPERIDINE DERIVATIVES, POLYMORPHS AND PSEUDORMOPHS THEREOF | HOECHST MARRION ROUSSEL, INC. (US) | 1995-11-23 | — | — | WO | claimed |
| US-4254130-A | ANTIALLERGENS | RICHARDSON-MERRELL INC. (US) | 1981-03-03 | — | — | US | claimed |
| US-10696633-B2 | Process for the preparation of fexofenadine and of intermediates used therein | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2020-06-30 | — | — | US | disclosed |
| EP-3365327-B1 | PROCESS FOR THE PREPARATION OF FEXOFENADINE AND OF INTERMEDIATES USED THEREIN | SANOFI AVENTIS DEUTSCHLAND (DE) | 2019-11-20 | — | — | EP | disclosed |
| US-20180297951-A1 | PROCESS FOR THE PREPARATION OF FEXOFENADINE AND OF INTERMEDIATES USED THEREIN | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2018-10-18 | — | — | US | disclosed |
| EP-3365327-A1 | PROCESS FOR THE PREPARATION OF FEXOFENADINE AND OF INTERMEDIATES USED THEREIN | Sanofi-Aventis Deutschland GmbH (DE) | 2018-08-29 | — | — | EP | disclosed |
| WO-1995031437-A1 | PROCESSES FOR PREPARING ANHYDROUS AND HYDRATE FORMS OF ANTIHISTAMINIC PIPERIDINE DERIVATIVES, POLYMORPHS AND PSEUDORMOPHS THEREOF | HOECHST MARRION ROUSSEL, INC. (US) | 1995-11-23 | — | — | WO | disclosed |
| US-4285958-A | ANTIALLERGENS; ANTIHISTAMINES; BRONCHODILATOR AGENTS | RICHARDSON-MERRELL INC. (US) | 1981-08-25 | — | — | US | disclosed |
| US-4285957-A | ANTIALLERGENS; ANTIHISTAMINES; BRONCHODILATOR AGENTS | RICHARDSON-MERRELL INC. (US) | 1981-08-25 | — | — | US | disclosed |
| US-4254130-A | ANTIALLERGENS | RICHARDSON-MERRELL INC. (US) | 1981-03-03 | — | — | US | disclosed |
| US-4254129-A | ANTIALLERGENS, BRONCHODILATORS, ANTIHISTAMINES; 4-DIPHENYLMETHYL PIPERIDINO-ALKANOLS | RICHARDSON-MERRELL INC. (US) | 1981-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020193603-A1 | Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudomorphs thereof | HRH1, HRH2, HRH4 | CYP2J2 270/4885CYP3A4 57/4885CYP2C9 135/4885 |
| US-20030045722-A1 | Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudomorphs thereof | HRH1, HRH2, HRH4 | CYP2J2 270/4885CYP3A4 57/4885CYP2C9 135/4885 |
| US-10696633-B2 | Process for the preparation of fexofenadine and of intermediates used therein | CYP4F2, CYP4F3, NISCH | CYP2J2 186/4885CYP3A4 15/4885CYP2C9 16/4885 |
| US-20010012896-A1 | Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudomorphs thereof | HRH1, HRH2, HRH4 | CYP2J2 150/4885CYP3A4 61/4885CYP2C9 146/4885 |
| US-20020193600-A1 | Process for preparing anyhdrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudomorphs thereof | HRH1, HRH2, HRH4 | CYP2J2 531/4885CYP3A4 82/4885CYP2C9 160/4885 |
| US-20010025106-A1 | Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudomorphs thereof | HRH1, HRH2, HRH4 | CYP2J2 270/4885CYP3A4 57/4885CYP2C9 135/4885 |
| US-20010014741-A1 | Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudomorphs thereof | HRH1, HRH2, HRH4 | CYP2J2 270/4885CYP3A4 57/4885CYP2C9 135/4885 |
| US-20180297951-A1 | PROCESS FOR THE PREPARATION OF FEXOFENADINE AND OF INTERMEDIATES USED THEREIN | CYP4F2, CYP4F3, NISCH | CYP2J2 186/4885CYP3A4 15/4885CYP2C9 16/4885 |
| US-20020193601-A1 | Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudomorphs thereof | HRH1, HRH2, HRH4 | CYP2J2 270/4885CYP3A4 57/4885CYP2C9 135/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.