SCHEMBL4880736

SCHEMBL4880736

O=C(O)Cc1c(C(=O)Nc2cccnc2)nn(-c2ccc(Cl)cc2Cl)c1-c1ccc(Cl)cc1

nearest known ligand 0.66

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 14/20 0.66
CNR2 P34972 7/20 0.58
PPARA Q07869 2/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4890177 0.92 CNR1 (0.78) CNR1
SCHEMBL14087102 0.88 CNR1 (0.61) CNR1CNR2PPARA
SCHEMBL4632902 0.88 CNR1 (0.85) CNR1CNR2
SCHEMBL4882114 0.84 CNR1 (0.68) CNR1CNR2PPARA
SCHEMBL4888372 0.83 CNR1 (0.59) CNR1CNR2PPARA
SCHEMBL4878527 0.83 CNR1 (0.57) CNR1CNR2PPARA
SCHEMBL4887625 0.82 CNR1 (0.58) CNR1CNR2PPARA
SCHEMBL4884798 0.80 CNR1 (0.61) CNR1CNR2PPARA
SCHEMBL4878550 0.79 CNR1 (0.54) CNR1CNR2PPARA
SCHEMBL4888376 0.78 CNR1 (0.55) CNR1CNR2PPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080200527-A1 Cannabinoid Receptor Modulators CAREX SA (FR) 2008-08-21 US disclosed
US-20080200527-A1 Cannabinoid Receptor Modulators CAREX SA (FR) 2008-08-21 US disclosed
US-20080200527-A1 Cannabinoid Receptor Modulators CAREX SA (FR) 2008-08-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080200527-A1 Cannabinoid Receptor Modulators CNR1, CNR2, HCRTR2 CNR1 1/4885CNR2 2/4885PPARA 497/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.