Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 15/20 | 0.81 |
| ▸ | KMT2A | Q03164 | 15/20 | 0.81 |
| ▸ | MAPT | P10636 | 14/20 | 0.81 |
| ▸ | ALOX12 | P18054 | 10/20 | 0.81 |
| ▸ | LMNA | P02545 | 8/20 | 0.81 |
| ▸ | GPR55 | Q9Y2T6 | 4/20 | 0.81 |
| ▸ | HTT | P42858 | 4/20 | 0.81 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.81 |
| ▸ | GAA | P10253 | 3/20 | 0.79 |
| ▸ | NPSR1 | Q6W5P4 | 7/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.72 |
| ▸ | ALOX15 | P16050 | 6/20 | 0.72 |
| ▸ | TP53 | P04637 | 5/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.72 |
| ▸ | USP2 | O75604 | 5/20 | 0.72 |
| ▸ | XBP1 | P17861 | 2/20 | 0.72 |
| ▸ | CNR1 | P21554 | 3/20 | 0.67 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.65 |
| ▸ | TSHR | P16473 | 4/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4880114 | 0.94 | MEN1 (0.74) | MEN1KMT2AMAPTALOX12LMNA | |
| SCHEMBL4884164 | 0.90 | MEN1 (1.00) | MEN1KMT2AMAPTALOX12LMNA | |
| SCHEMBL4884213 | 0.89 | MEN1 (0.77) | MEN1KMT2AMAPTALOX12LMNA | |
| SCHEMBL4879474 | 0.89 | MEN1 (0.77) | MEN1KMT2AMAPTALOX12LMNA | |
| SCHEMBL4881413 | 0.86 | MEN1 (0.91) | MEN1KMT2AMAPTALOX12LMNA | |
| SCHEMBL19319702 | 0.85 | MEN1 (0.74) | MEN1KMT2AMAPTALOX12LMNA | |
| SCHEMBL4880262 | 0.84 | MEN1 (0.72) | MEN1KMT2AMAPTALOX12LMNA | |
| SCHEMBL4875821 | 0.84 | MEN1 (0.67) | MEN1KMT2AMAPTALOX12LMNA | |
| SCHEMBL4885698 | 0.83 | MEN1 (0.69) | MEN1KMT2AMAPTALOX12LMNA | |
| SCHEMBL1528332 | 0.82 | MEN1 (0.62) | MEN1KMT2AMAPTALOX12LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080090880-A1 | 3-(2-Hydroxyphenyl) Pyrazoles and Thier Use as Hsp90 Modulators | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2008-04-17 | — | — | US | claimed |
| EP-1799649-B1 | 3-(2-HYDROXYPHENYL) PYRAZOLES AND THEIR USE AS HSP90 MODULATORS | MERCK PATENT GMBH (DE) | 2014-06-25 | — | — | EP | disclosed |
| US-20080090880-A1 | 3-(2-Hydroxyphenyl) Pyrazoles and Thier Use as Hsp90 Modulators | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2008-04-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080090880-A1 | 3-(2-Hydroxyphenyl) Pyrazoles and Thier Use as Hsp90 Modulators | HSP90AB1, HSP90AA1, HSP90AB2P | MEN1 4568/4885KMT2A 4029/4885MAPT 2220/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.