Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 17/20 | 0.60 |
| ▸ | PIK3CG | P48736 | 17/20 | 0.60 |
| ▸ | PIK3CA | P42336 | 13/20 | 0.60 |
| ▸ | PIK3CB | P42338 | 9/20 | 0.60 |
| ▸ | PI4KB | Q9UBF8 | 4/20 | 0.54 |
| ▸ | PIK3C3 | Q8NEB9 | 3/20 | 0.54 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.54 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.54 |
| ▸ | PI4KA | P42356 | 1/20 | 0.54 |
| ▸ | PRKDC | P78527 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL49024 | 0.98 | PIK3CG (0.61) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL49258 | 0.88 | PIK3CG (0.58) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL49545 | 0.87 | PIK3CG (0.57) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL48392 | 0.84 | PIK3CG (0.83) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL48762 | 0.83 | PIK3CD (0.67) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL49041 | 0.82 | PIK3CD (0.66) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL49493 | 0.82 | PIK3CG (0.62) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL13525246 | 0.82 | PIK3CD (0.57) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL48690 | 0.81 | PIK3CD (0.65) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB | |
| SCHEMBL434648 | 0.81 | PIK3CD (0.65) | PIK3CDPIK3CGPIK3CAPIK3CBPI4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129541-B2 | 5-phenylthiazole derivatives and use as PI3 kinase inhibitors | NOVARTIS AG (CH) | 2012-03-06 | — | — | US | disclosed |
| EP-2311818-A1 | Combination of a 5-phenylthiazole compound as PI3 kinase inhibitor with an antiinflammatory, bronchodilatory or antihistamine drug | Novartis AG (CH) | 2011-04-20 | — | — | EP | disclosed |