Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 5/20 | 0.56 |
| ▸ | CA2 | P00918 | 5/20 | 0.56 |
| ▸ | CA12 | O43570 | 1/20 | 0.56 |
| ▸ | CA9 | Q16790 | 1/20 | 0.56 |
| ▸ | CDK2 | P24941 | 2/20 | 0.54 |
| ▸ | CDK4 | P11802 | 1/20 | 0.54 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | AURKA | O14965 | 5/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.53 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 3/20 | 0.49 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4884494 | 0.99 | CA1 (0.55) | CA1CA2CA12CA9CDK2 | |
| SCHEMBL13392346 | 0.90 | CDK2 (0.56) | CA1CA2CDK2CDK4CCNE1 | |
| Hydrochloric Acid SCHEMBL3300332 | 0.89 | CDK2 (0.55) | CA1CA2CDK2CDK4CCNE1 | |
| SCHEMBL657412 | 0.89 | MAPK1 (0.62) | CDK2MAPK1MEN1NPC1LMNA | |
| Hydrochloric Acid SCHEMBL27735100 | 0.88 | AURKA (0.57) | CA1CA2CA12CA9CDK2 | |
| SCHEMBL14020165 | 0.87 | CDK2 (0.59) | CA1CA2CDK2CDK4CCNE1 | |
| SCHEMBL3197568 | 0.86 | MAPK1 (0.73) | CDK2MAPK1MEN1NPC1LMNA | |
| Hydrochloric Acid SCHEMBL3304512 | 0.86 | CDK2 (0.58) | CA1CA2CDK2CDK4CCNE1 | |
| SCHEMBL13392205 | 0.85 | NPC1 (0.75) | CA1CA2CDK2CDK4CCNE1 | |
| Hydrochloric Acid SCHEMBL3299181 | 0.84 | NPC1 (0.73) | CA1CA2CDK2CDK4CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080269170-A1 | Novel 2,4-Dianilinopyrimidine Derivatives, the Preparation Thereof, Their Use as Medicaments, Pharmaceutical Compositions and, in Particular, as IKK Inhibitors | SANOFI-AVENTIS (FR) | 2008-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269170-A1 | Novel 2,4-Dianilinopyrimidine Derivatives, the Preparation Thereof, Their Use as Medicaments, Pharmaceutical Compositions and, in Particular, as IKK Inhibitors | NFKBIA, IKBKB, IKBKE | CA1 4640/4885CA2 3293/4885CA12 4820/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.