Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.44 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 10/20 | 0.49 |
| ▸ | NPC1 | O15118 | 10/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.49 |
| ▸ | MEN1 | O00255 | 6/20 | 0.49 |
| ▸ | HTT | P42858 | 6/20 | 0.49 |
| ▸ | POLB | P06746 | 5/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.49 |
| ▸ | BLM | P54132 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | ALPL | P05186 | 1/20 | 0.49 |
| ▸ | ALPI | P09923 | 1/20 | 0.49 |
| ▸ | ALPG | P10696 | 1/20 | 0.49 |
| ▸ | SYNJ2 | O15056 | 1/20 | 0.44 |
| ▸ | MLNR | O43193 | 1/20 | 0.44 |
| ▸ | SYNJ1 | O43426 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL4882559 | 1.00 | MAPT (0.49) | MAPTNPC1KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL14007229 | 0.87 | AR (0.57) | MAPTNPC1KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL14007222 | 0.77 | AR (0.55) | MAPTNPC1KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL14007232 | 0.77 | AR (0.57) | MAPTNPC1KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL10024114 | 0.76 | AR (0.54) | MAPTNPC1KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL5318897 | 0.75 | AR (0.76) | MAPTNPC1KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL5318903 | 0.75 | AR (0.76) | MAPTNPC1KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL14007212 | 0.75 | AR (0.78) | MAPTNPC1KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL10024115 | 0.73 | AR (0.76) | MAPTNPC1KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL21227879 | 0.72 | KMT2A (0.47) | MAPTNPC1KMT2ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080281105-A1 | Novel Quinolinium Salts and Derivatives | IMMUSOL INCORPORATED (US) | 2008-11-13 | — | — | US | disclosed |
| EP-1841428-A1 | NOVEL QUINOLINIUM SALTS AND DERIVATIVES | Immusol Incorporated (US) | 2007-10-10 | — | — | EP | disclosed |
| WO-2006078754-A1 | NOVEL QUINOLINIUM SALTS AND DERIVATIVES | IMMUSOL INCORPORATED (US) | 2006-07-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080281105-A1 | Novel Quinolinium Salts and Derivatives | NQO2, MCL1, KRAS | CHRM1 3383/4885CHRM3 3219/4885MAPT 2491/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.