⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29770800 | 0.81 | — | — | |
| SCHEMBL609820 | 0.81 | — | — | |
| SCHEMBL22678131 | 0.80 | — | — | |
| SCHEMBL29365050 | 0.80 | — | — | |
| SCHEMBL376483 | 0.79 | — | — | |
| SCHEMBL29467490 | 0.79 | — | — | |
| SCHEMBL841270 | 0.79 | — | — | |
| SCHEMBL19785439 | 0.75 | — | — | |
| SCHEMBL31416684 | 0.75 | — | — | |
| SCHEMBL14938822 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240360126-A1 | PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE | HOFFMANN-LA ROCHE INC. (US) | 2024-10-31 | — | — | US | disclosed |
| CN-118076604-A | Pyrazolo [3,4-b ] pyridine compounds for the treatment of autoimmune diseases | 豪夫迈·罗氏有限公司 | 2024-05-24 | — | — | CN | disclosed |
| CN-117323926-A | Gas treatment material and preparation method thereof | 蚌埠市天星树脂有限责任公司 | 2024-01-02 | — | — | CN | disclosed |
| US-20230382910-A1 | HETEROARYL COMPOUNDS FOR THE TREATMENT OF PAIN | VERTEX PHARMACEUTICALS INCORPORATED | 2023-11-30 | — | — | US | disclosed |
| CN-117065726-A | Environment-friendly adsorptive material and preparation method thereof | 蚌埠市天星树脂有限责任公司 | 2023-11-17 | — | — | CN | disclosed |
| WO-2023205778-A1 | HETEROARYL COMPOUNDS FOR THE TREATMENT OF PAIN | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-10-26 | — | — | WO | disclosed |
| WO-2023046806-A1 | PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2023-03-30 | — | — | WO | disclosed |
| US-20080214495-A1 | Heterocyclic Sulfonamide Derivatives as Inhibitors of Factor Xa | ASTRAZENECA AB (SE) | 2008-09-04 | — | — | US | disclosed |
| US-20080200431-A1 | 6-{4-[4-(3-Chloro-1H-indole-6-sulfonyl)-3-hydroxy-piperazine-1-carbonyl]-piperidin-1-yl}-2-methyl-2H-pyridazin-3-one for example; antithrombotic and anticoagulant; synthesis; combination therapy | ASTRAZENECA AB (SE) | 2008-08-21 | — | — | US | disclosed |
| WO-2007008143-A1 | HETEROCYCLIC SULFONAMIDE DERIVATIVES AS INHIBITORS OF FACTOR XA | ASTRAZENECA AB (SE) | 2007-01-18 | — | — | WO | disclosed |
| EP-1362050-B1 | PYRIMIDINE DERIVATIVES FOR INHIBITION OF CELL-PROLIFERATION | ASTRAZENECA AB (SE) | 2005-02-02 | — | — | EP | disclosed |
| US-6844341-B2 | Pyrimidine derivatives for inhibition of cell proliferation | ASTRAZENECA AB (SE) | 2005-01-18 | — | — | US | disclosed |
| US-20040097506-A1 | Pyrimidine derivatives for inhibition of cell proliferation | ASTRAZENECA AB (SE) | 2004-05-20 | — | — | US | disclosed |
| EP-1362050-A1 | PYRIMIDINE DERIVATIVES FOR INHIBITION OF CELL-PROLIFERATION | AstraZeneca AB (SE) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002066481-A1 | PYRIMIDINE DERIVATIVES FOR INHIBITION OF CELL-PROLIFERATION | ASTRAZENECA AB (SE) | 2002-08-29 | — | — | WO | disclosed |