SCHEMBL4883115

SCHEMBL4883115

CCCc1nc2c(N)nc(C)c(C)c2n1CCCS(=O)(=O)Nc1ccc(Cl)cc1Cl

nearest known ligand 0.38

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
TLR7 Q9NYK1 16/20 0.38
TLR8 Q9NR97 7/20 0.37
PTGES2 Q9H7Z7 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4868653 0.96 TLR7 (0.43) TLR7TLR8
SCHEMBL4873557 0.93 TLR7 (0.43) TLR7TLR8
SCHEMBL4876728 0.93 TLR7 (0.40) TLR7TLR8PTGES2
SCHEMBL4870522 0.93 TLR7 (0.42) TLR7TLR8
SCHEMBL4876740 0.88 TLR7 (0.36) TLR7TLR8PTGES2
SCHEMBL4879324 0.87 TLR7 (0.35) TLR7TLR8
SCHEMBL4791912 0.85 TLR7 (0.35) TLR7TLR8
SCHEMBL4795262 0.85 TLR7 (0.41) TLR7TLR8
SCHEMBL4880838 0.85 TLR7 (0.35) TLR7TLR8PTGES2
SCHEMBL4877651 0.83 TLR7 (0.41) TLR7TLR8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1513524-A4 ETHER SUBSTITUTED IMIDAZOPYRIDINES 3M INNOVATIVE PROPERTIES CO (US) 2008-09-03 EP disclosed
EP-1513524-A2 ETHER SUBSTITUTED IMIDAZOPYRIDINES 3M Innovative Properties Company (US) 2005-03-16 EP disclosed
WO-2003103584-A2 ETHER SUBSTITUTED IMIDAZOPYRIDINES 3M INNOVATIVE PROPERTIES COMPANY (US) 2003-12-18 WO disclosed